Table 4 Odds ratio, sensitivity, specificity, positive and negative predictive values for predicting current asthma at 10 years of age in subjects at 2 years with severity scores at 2 years of age from 1 to 12, as well as approximated indices, as suggested by Castro-Rodriguez et al applied to our dataset8
Odds ratio (95% CI)Sensitivity (%) (95% CI)Specificity (%) (95% CI)PPV (%) (95% CI)NPV (%) (95% CI)
Severity score 19.8 (5.1, 18.5)87.6 (79.6, 92.8)58.0 (52.7, 63.0)36.5 (30.6, 42.8)94.4 (90.5, 96.8)
Severity score 28.0 (4.6, 13.9)81.4 (72.6, 87.9)64.5 (59.4, 69.3)38.7 (32.3, 45.6)92.7 (88.7, 95.3)
Severity score 35.2 (3.2, 8.5)62.9 (53.0, 71.8)75.6 (70.8, 79.8)41.5 (33.8, 49,6)86.1 (83.9, 91.3)
Severity score 46.0 (3.7, 9.7)61.9 (51.9, 70.9)78.7 (74.1, 82.6)44.4 (36.3, 52.9)88.2 (84.2, 91.3)
Severity score 58.0 (4.8, 13.2)55.6 (45.8, 65.2)86.4 (82.4, 89.6)52.9 (43.3, 62.3)87.6 (83.7, 90.7)
Severity score 67.9 (4.7, 13.1)51.5 (41.7, 61.2)88.1 (84.3, 91.1)54.3 (44.2, 64.1)86.8 (82.9, 90.0)
Severity score 74.8 (2.6, 8.8)26.8 (19.0, 36.4)92.9 (89.7, 95.1)51.0 (37.7, 64.1)82.2 (78.1, 85.6)
Severity score 84.5 (2.5, 8.4)25.8 (18.1, 35.392.9 (89.7, 95.1)50.0 (36.6, 63.4)82.0 (77.9, 85.4)
Severity score 94.8 (2.9, 11.5)12.4 (7.2, 20.4)97.2 (94.9, 98.4)54.5 (34.7, 73.1)80.1 (76.0, 83.3)
Severity score 103.9 (1.6, 9.7)10.3 (5.7, 19.7)97.2 (94.9, 98.5)50.0 (29.9, 70.1)79.7 (75.7, 83.3)
Severity score 115.6 (0.91, 33.9)3.1 (1.1, 8.7)99.4 (98.0, 99.8)60.0 (23.1, 88.2)78.8 (74.8, 82.4)
Severity score 123.7 (0.51, 26.5)2.1 (0.6, 7.2)99.4 (98.0, 99.8)50.0 (15.0, 85.0)78.7 (74.6, 82.2)
Positive stringent index*6.4 (3.9–10.4)56.7 (46.8–66.1)83.0 (78.7–86.5)47.8 (38.9–56.9)87.4 (83.4–90.6)
Positive loose index*5.6 (3.5–9.0)59.8 (49.8–69.0)79.0 (74.4–82.9)43.9 (35.8–52.5)87.7 (83.6–90.9)
  • *Data in the present study have been approximated to the criteria used in asthma indices (stringent and loose) suggested by Castro-Rodriguez et al.8

  • NPV, negative predictive value; PPV, positive predictive value.