Study | Subject | Asthma diagnosis* | Intervention | Duration | Resolves at follow-up | |||||
Surgical interventions | ||||||||||
Ahroni32 2005 USA | Total = 179 | History of asthma | LAGB | 1 y | Mean BMI 32.3 (7.0) kg/m2 (↓18.5); ↓ in use of asthma meds (30%); asthma much better (74%); no change in SF-36 (quality of life) | |||||
Age 19–70 (χ = 44) | ||||||||||
Mean BMI 46 kg/m2 | ||||||||||
Asthma n = 24 (13.4%) | ||||||||||
Dhabuwala39 2000 New Zealand | Total = 157; 80% female | History of asthma | SRGBP | 2.5 y | BMI 28 kg/m2 (20–52); asthma resolved−50%; improved—26%, unchanged—14%; reduced medication use (84%) | |||||
Age 15–62 (χ = 41), | Use of meds | (0–9.5) | ||||||||
Mean BMI 45 kg/m2 | ||||||||||
Asthma n = 34 (21.7%) | ||||||||||
Dixon33 1999 Australia | Total = 380; 88% female | Physician diagnosis | LAGB | 12 mo | BMI 32.9 kg/m2; asthma score 14.3 (↓30.2 points), asthma severity score 2.03 (↓1.63 points); daily impact score 1.21 (↓.87 points); ↓use of daily meds (81%), no hospitalisation, 34% resolved symptoms | |||||
Age 17–69 (median 39) | ||||||||||
Mean BMI 46 kg/m2 | ||||||||||
Asthma n = 32 (8.4%) | ||||||||||
Hall34 1990 Australia | Total = 310; 93% female | History of asthma | VBGP | 3 y | Wt (kg) median 76–93; discontinued asthma meds (50%) | |||||
Age 28–40 (median 34) | Use of meds | Gastric bypass | ||||||||
Wt range 110–115 kg | ||||||||||
Asthma n = 12 (3.9%) | ||||||||||
Macgregor26 1993 USA | Total = 40; 80% female | History of asthma | VBGP | 2–11 (χ = 4) y | BMI 30 at 4 y; 90% improved asthma symptoms; 48% remission, discontinued meds: moderate (42%); severe (36%) | |||||
Age 23–68; mean BMI 46 | Use of meds | Gastric bypass | ||||||||
Asthma n = 40 (100%) | Frequency of attacks | |||||||||
Murr35 1995 USA | Total = 62; 80% female | History of asthma | VBGP | 1–3 y | Wt loss 44 (5)% at 1 y; wt loss 33 (6)% at 3 y; decreased use of asthma meds (100%) | |||||
Age 50–71 (χ = 57) | Use of meds | Gastric bypass | ||||||||
Mean wt 125 (4) kg | BPD-DS | |||||||||
Asthma n = 6 (9.6%) | ||||||||||
Narbro36 2002 Sweden | Total = 1294; 69% female | History of asthma | Gastric banding | 6 y | ↓Weight 16%; no difference in cost of asthma meds between both the intervention group and reference group at follow-up | |||||
Age 37–60 (χ = 48) | Use of meds | Gastric bypass | ||||||||
Mean BMI 41 kg/m2 | VBGP | |||||||||
Asthma n = not reported | ||||||||||
O’Brien37 2002 Australia | Total = 709; 85% female | Asthma severity score | LAGB | 1 y | Mean BMI 31 kg/m2; asthma resolved (30%); no hospitalisations; discontinued asthma meds (60%); no oral steroids needed | |||||
Median age 41 (16–71) | Use of meds | |||||||||
Mean BMI 45 (7) kg/m2 | ||||||||||
Asthma n = 33 (4.6%) | ||||||||||
Simard29 2004 Canada | Total = 398; 70% female | History of asthma | BPD-DS | 2 y | Of the 139 at follow-up: BMI 30 kg/m2; improved severity of asthma (79%) | |||||
Age 22–67 (mean 45) | Use of meds | |||||||||
Mean BMI 50 kg/m2 | ||||||||||
Asthma n = 34 (9%) | ||||||||||
Spivak38 2005 USA | Total = 163; 90% female | History of asthma | Lap band | 3 y | Mean BMI 35 (↓10 kg/m2); 82% resolved asthma | |||||
Age 18–63 (mean 42) | Use of meds | |||||||||
Mean BMI 45 kg/m2 | ||||||||||
Asthma n = 11 (6.7%) | ||||||||||
Medical interventions | ||||||||||
Sugerman30 2003 USA | Total = 33 | History of asthma | Gastric bypass | Up to 14 y | Asthma resolved (100%) | |||||
Asthma n = 1 (3.3%) | ||||||||||
Mean age 16 (12–18) | ||||||||||
Mean BMI 52 kg/m2 | ||||||||||
Aaron31 2004 Canada | Total = 58; 100% female | Physician diagnosis | Wt loss programme | 6 mo | Mean wt ↓20 kg (19%); for 10% wt loss, FVC ↑92 ml; for 10% wt loss, FEV ↑73 ml; improvement in symptoms (p<0.05); no hospitalisations or ER visits | |||||
Age 44 (13) | ||||||||||
Mean wt 115 (26) kg | ||||||||||
Asthma n = 24 (41%) | ||||||||||
Hakala19 2000 Finland | Total = 14; 80% female | Physician diagnosis | Low cal diet | 8 wk | BMI 32.1 kg/m2 (↓5.1 kg/m2); dyspnoea score 8.1 (↓6.5); use of rescue meds 0.4 does/day (↓0.2) | |||||
Age 25–62 | ||||||||||
Mean BMI 37 (33–43) | ||||||||||
Asthma n = 14 (100%) | ||||||||||
Johnson28 2007 USA | Total = 10, 80% female | Physician diagnosis | Low cal diet | 8 wk | Weight 96.4 kg (↓8%); improved asthma control on ACQ | |||||
Age adult | ||||||||||
Mean wt 104.9 kg | ||||||||||
Asthma n = 10 (100%) | ||||||||||
Stenius-Aarniala27 2000 Finland | Total = 38 | Physician diagnosis | Low cal diet for 8 weeks | 1 y | Mean wt: treatment grp ↓11 kg (11%), control grp 0.3%; median No of exacerbations: treatment group 1 (0–4), control grp 1 (0–7); median No of oral steroids courses: treatment group 1 (0–3), control grp 2 (0–3) | |||||
Age 18–60 | ||||||||||
BMI 30–42 kg/m2 | ||||||||||
Asthma 38 (100%) |
*History of asthma denotes subject was identified as an individual with asthma.
ACQ, Juniper Asthma Control Questionnaire; BMI, body mass index; BPD-DS, biliopancreatic diversion with duodenal switch; FEV, forced expiratory volume; FVC, forced vital capacity; LAGB, laparoscopic adjustable gastric banding; PEF, peak expiratory flow; PFT, pulmonary function tests; SEK, Swedish Kroners; SRGBP, silastic ring gastric bypass; VBGP, vertical banded gastroplasty.