Table 2 Unadjusted association of baseline BHR and GST genotypes with self-report of physician-diagnosed asthma after 11 years of follow-up
Subjects at risk at baseline (n)New asthma reportsp Value for difference
Baseline BHR
    Without BHR380094/2.5%
    With BHR62650/8.0%<0.001
GSTP1 Ile105Val
    Ile/Val or Val/Val235560/2.6%
    Ile/Ile207177/4.0%0.005
GSTM1
    No deletion210071/3.4%
    Deletion232273/3.1%0.66
GSTT1
    No deletion3600119/3.3%
    Deletion82225/3.0%0.70

  • BHR, bronchial hyperresponsiveness; GST, glutathione S-transferase.