Drug | Route | Age/weight | Dose | Frequency (times daily) | Maximum dose | Duration |
Amphotericin (doses are for liposomal formulation which is better tolerated) | IV (infusion rate varies with preparation) | Test dose | 100 μg/kg | 1 dose | 100 μg/kg | 1 dose |
Start | 1 mg/kg/day | 1 | 5 mg/kg/day | 2 weeks | ||
Increase by | 1 mg/kg/day | 1 | ||||
Maximum dose | 5 mg/kg/day | 1 | ||||
Ceftazidime | IV (30 min infusion) | 1 month–18 years | 50 mg/kg | 3 | 3 g ×3 daily | 2 weeks |
Ciprofloxacin | Oral | 1 month–5 years | 15 mg/kg | 2 | 750 mg ×2 daily | 2 weeks |
5–18 years | 20 mg/kg | 2 | ||||
Colistin | IV | <60 kg | 25000 units/kg | 3 | 2 million units ×3 daily | 2 weeks |
(30 min infusion) | >60 kg | 1–2 million units | 3 | |||
Co-trimoxazole | Oral | 6 weeks–6 months | 120 mg | 2 | 960 mg ×2 daily | 2 weeks |
6 months–6 years | 240 mg | 2 | ||||
6–12 years | 480 mg | 2 | ||||
>12 years | 960 mg | 2 | ||||
Dornase alfa | Nebulised | >5 years | 2.5 mg | 1 | As indicated | |
Doxycycline | Oral | >12 years only | 200 mg loading dose, then 100 mg | 1 dose | 200 mg | 2 weeks |
Give 200 mg in severe cases | 1 | |||||
1 | ||||||
Flucloxacillin | IV (30 min infusion) | 25 mg/kg | 4 | 1 g ×4 daily | 2 weeks | |
Itraconazole | Oral | <12 years | 3–5 mg/kg | 1 | 200 mg ×2 daily has been used | Maintenance |
>12 years | 200 mg | 1 | ||||
Linezolid | IV/oral (IV rarely needed) | 1 month–12 years | 10 mg/kg | 3 | 600 mg ×2 daily | 10–14 days |
>12 years | 600 mg | 2 | ||||
Meropenem | IV (bolus over 5 min or 15–30 min infusion) | 1 month–18 years | 40 mg/kg | 3 | 2 g ×3 daily | 2 weeks |
Prednisolone (treatment ABPA) | Oral | 0.5–1 mg/kg | 1 | 2–3 weeks | ||
2–3 months | ||||||
0.5–1 mg/kg | Alternate days | 2–3 months | ||||
Prednisolone | Oral | 1–2 mg/kg | 1 | 40 mg | 2 weeks and review | |
Tobramycin (trough level day 2) | IV (30 min infusion) | 10 mg/kg | 1 | Max starting dose 660 mg | 2 weeks | |
Teicoplanin | IV (bolus or 30 min infusion) | Loading dose | 10 mg/kg | 2 | 400 mg | ×3 doses |
Continue on | 10 mg/kg | 1 | 2 weeks | |||
Temocillin | IV (bolus over 3–4 min or 30–40 min infusion) | >12 years and >45 kg | 1–2 g | 2 | 2 g | 2 weeks |
Many drugs, though commonly used in children, do not have a marketing authorisation for use in this age group. Some drugs listed in the table will not have a marketing authorisation for this indication or for the dose given here, although there will be evidence to support their use. This formulary is provided to aid safe and effective prescribing for patients with cystic fibrosis, but the user is advised to check all doses against a standard reference such as the British National Formulary (BNF) (http://www.bnf.org/bnf/),26 the BNF for children (http://bnfc.org/bnfc/)27 or the UK CF Trust Antibiotic Guidelines.24