Table 3 Relationships between the response to chemotherapy and immunohistochemical parameters (univariate analysis)

IHC parameters	Responders (CR+PR)	Non-responders (SD+PD)	Response rate (%)	Risk value (95% CI)	p Value*	PD rate (%)	p Value*
pRb
Negative	3	5	37.5	0.692 (0.204 to 2.353)	0.686	37.5	0.123
Positive	10	10	50.0			10.0
Total	13	15
Cyclin D1
Negative	10	11	47.6	0.865 (0.236 to 3.174)	1.000	14.3	0.574
Positive	3	4	42.9			28.6
Total	13	15
P16
Negative	4	10	28.6	0.222 (0.045 to 1.094)	0.061	21.4	1.000
Positive	9	5	64.3			14.3
Total	13	15
P53
Negative	10	3	76.9	0.288 (0.104 to 0.803)	0.002	0.0	0.044
Positive	3	12	20.0			33.3
Total	13	15
P21
Negative	6	14	30.0	0.061 (0.006 to 0.613)	0.011	20.0	0.654
Positive	7	1	87.5			12.5
Total	13	15
Ki-67 LI
LI <20%	5	6	45.5	1.026 (0.565 to 1.862)	0.937	18.2	1.000
LI >20%	8	9	47.0			17.6
Total	13	15

CI, confidence interval; CR, complete response; IHC, immunohistochemical; LI, labeling index; PD, progressive disease; PR, partial response; SD, stable disease.
*χ² test or Fisher exact test.