| N | LS Mean (SE)* | Varenicline vs NRT | ||||
| Difference (SE) | 95% CI | p Value | Effect size† | |||
| Varenicline | ||||||
| Urge to smoke | 367 | 1.35 (0.04) | −0.32 (0.06) | –0.44 to −0.21 | <0.001 | –0.37 |
| Negative effect | 369 | 0.63 (0.03) | –0.16 (0.04) | –0.24 to –0.07 | <0.001 | –0.21 |
| Restlessness | 368 | 0.76 (0.04) | –0.20 (0.05) | –0.31 to –0.10 | <0.001 | –0.21 |
| Increased appetite | 368 | 1.07 (0.04) | 0.09 (0.06) | –0.02 to 0.21 | 0.116 | 0.12 |
| Insomnia | 368 | 0.70 (0.04) | −0.07 (0.05) | –0.17 to 0.04 | 0.207 | −0.07 |
| NRT | ||||||
| Urge to smoke | 366 | 1.67 (0.04) | ||||
| Negative effect | 366 | 0.79 (0.03) | ||||
| Restlessness | 366 | 0.96 (0.04) | ||||
| Increased appetite | 364 | 0.97 (0.04) | ||||
| Insomnia | 366 | 0.76 (0.04) | ||||
NRT, nicotine replacement therapy.
*Higher scores indicate greater intensity of symptoms. Response scale: 0 (not at all) to 4 (extreme).
†Effect size, LS mean difference divided by the pooled SD at baseline (pooled by centre).