Outcome | Predictor | Mean effect, compared with first quartile (95% CI) | p Value for predictor | p Value for trend |
Odds ratio for death at 180 days | Second quartile RAGE | 0.77 (0.37 to 1.57) | 0.003 | 0.008 |
Third quartile RAGE | 0.86 (0.41 to 1.80) | |||
Fourth quartile RAGE | 2.73 (1.31 to 5.68) | |||
Ventilator free days | Second quartile RAGE | 0.1 (−3.0 to 3.1) | ||
Third quartile RAGE | 0.1 (−3.0 to 3.4) | 0.01 | 0.01 | |
Fourth quartile RAGE | −4.2 (−7.3 to −1.1) | |||
Organ failure free days | Second quartile RAGE | −2.4 (−5.5 to 0.8) | ||
Third quartile RAGE | −2.3 (−5.6 to 1.0) | 0.001 | 0.0003 | |
Fourth quartile RAGE | −6.4 (−9.5 to −3.2) |
All analyses adjusted for age, gender, APACHE III, sepsis and trauma.
APACHE, Acute Physiology and Chronic Health Evaluation; RAGE, receptor for advanced glycation end products.