General
| |
Body weight <70% or >130% of idealMoribund/bed-ridden | Age >65 yearsMechanically ventilatedSevere kyphoscoliosis |
|
Medical
| |
Poor renal function (creatinine clearance <50 ml/min) | Osteoporosis |
Poorly-controlled diabetes |
Infection with HIV | High-dose corticosteroids (prednisolone >20 mg/day) |
Recent or active malignancy |
HBsAg positive | Colonisation with fungi or atypical mycobacteria |
Hepatitis C with biopsy-proven liver disease |
Progressive non-pulmonary disease (eg, neuromuscular disease, liver cirrhosis) | |
Pan-resistant organisms | |
| |
Psychosocial
| |
Substance addiction (alcohol, tobacco or narcotics)Uncontrolled psychosis | Uncommitted/poor compliancePoor psychosocial supportSevere psychoaffective disorder |