Table E5 Correlations between cells and mediators

Mediator or cell line	Data used for correlations PCC (p)	Sputum neutrophils	LTB4	CXCL8	TNFα	MPO	IL-1ß	GROα
Sputum neutrophils	1 day		0.5 (0.07)	0.6 (0.02)	0.46 (0.09)	0.18 (0.53)	0.60 (0.02)	0.13 (0.7)
	3 days		0.75 (0.01)	0.8 (<0.001)	0.84 (<0.001)	0.2 (0.5)	0.77 (0.001)	0.16 (0.6)
	5 days		0.61 (0.01)	0.66 (0.005)	0.71 (0.003)	0.2 (0.5)	0.77 (0.001)	0.3 (0.36)
	11 days		0.7 (0.008)	0.67 (0.004)	0.81 (<0.001)	0.13 (0.64)	0.83 (<0.001)	0.25 (0.4)
Sputum macrophages	1 day	0.38 (0.17)	0.006 (0.9)	0.1 (0.7)	0.08 (0.8)	−0.35 (0.22)	−0.08 (0.8)	0.08 (0.8)
	3 days	0.45 (0.1)	0.05 (0.89)	0.22 (0.44)	0.09 (0.73)	−0.37 (0.2)	0.09 (0.73)	0.22 (0.44)
	5 days	0.29 (0.3)	−0.15 (0.6)	0.11 (0.7)	0.05 (0.8)	−0.14 (0.6)	0.07 (0.8)	0.16 (0.6)
	11 days	0.4 (0.12)	−0.19 (0.5)	0.19 (0.51)	0.09 (0.8)	−0.39 (0.16)	0.03 (0.9)	0 (0.9)

Data describes the relationships between mediators and cell counts when one days data is used (here, the first day), or the mean of the first 3, 5 or all 11 days’ data. Relationships are expressed as Pearsons Correlation Co-efficient (PCC) and p value.