Table E4 Correlations between mediators

Mediator or cell line	Data used for correlations PCC (p)	LTB4	CXCL8	IL-1ß	TNFα	MPO	GROα
LTB4	1 day		0.57 (0.051)	0.78 (0.002)	0.87 (<0.001)	0.65 (0.006)	0.12 (0.7)
	3 days		0.66 (0.01)	0.84 (<0.001)	0.84 (<0.001)	(0.6 (0.012)	0.16 (0.6)
	5 days		0.5 (0.07)	0.8 (<0.001)	0.77 (0.002)	0.62 (0.011)	0.01 (0.99)
	11 days		0.54 (0.03)	0.8 (<0.001)	0.82 (<0.001)	0.58 (0.02)	0.03 (0.9)
CXCL8	1 day	0.57 (0.051)		0.85 (<0.001)	0.84 (<0.001)	0.61 (0.01)	0.22 (0.5)
	3 days	0.66 (0.01)		0.84 (<0.001)	0.83 (<0.001)	0.5 (0.07)	0.23 (0.5)
	5 days	0.5 (0.07)		0.75 (0.001)	0.8 (<0.001)	0.51 (0.04)	0.6 (0.03)
	11 days	0.54 (0.03)		0.72 (<0.001)	0.83 (<0.001)	0.4 (0.12)	0.56 (0.02)
IL-1ß	1 day	0.78 (0.002)	0.85 (<0.001)		0.84 (<0.001)	0.34 (0.2)	0.1 (0.8)
	3 days	0.84 (<0.001)	0.84 (<0.001)		0.96 (<0.001)	0.4 (0.1)	0.06 (0.9)
	5 days	0.8 (<0.001)	0.75 (0.001)		0.87 (<0.001)	0.4 (0.1)	0.15 (0.6)
	11 days	0.8 (<0.001)	0.72 (<0.001)		0.85 (<0.001)	0.31 (0.24)	0.13 (0.6)

Data describes the relationships between mediators and cell counts when one days data is used (here, the first day), or the mean of the first 3, 5 or all 11 days’ data. Relationships are expressed as Pearsons Correlation Co-efficient (PCC) and p value.