Table 3 Trough lung function measurements on day 14 of treatment

	Adjusted mean change from baseline			Treatment differences (97.5% CI, p value)
	SFC+TIO	TIO	SFC	Triple vs TIO	Triple vs SFC
Trough FEV₁ (l)	0.29	0.08	0.18	0.21 (0.109, 0.315) p<0.001	0.11 (0.007, 0.214) p = 0.017
Trough FVC (l)	0.39	0.19	0.26	0.20 (0.048, 0.347) p = 0.004	0.13 (−0.026, 0.277) p = 0.062
	Adjusted geometric mean ratio to baseline
Trough IC (l)	1.13	1.04	1.08	1.08 (1.019, 1.150) p = 0.004	1.05 (0.982, 1.112) p = 0.109
Trough RV (l)	0.90	0.96	0.92	0.93 (0.875, 0.991) p = 0.011	0.98 (0.919, 1.044) p = 0.459
Trough TLC (l)	1.00	1.00	1.00	1.00 (0.980, 1.026) p = 0.776	1.00 (0.981, 1.027) p = 0.721

IC, Inspiratory capacity; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; RV, residual volume; SFC, salmeterol/fluticasone propionate combination; TIO, tiotropium; TLC, total lung capacity.