Adjusted mean change from baseline | Treatment differences (97.5% CI, p value) | ||||
SFC+TIO | TIO | SFC | Triple vs TIO | Triple vs SFC | |
Trough FEV1 (l) | 0.29 | 0.08 | 0.18 | 0.21 (0.109, 0.315) p<0.001 | 0.11 (0.007, 0.214) p = 0.017 |
Trough FVC (l) | 0.39 | 0.19 | 0.26 | 0.20 (0.048, 0.347) p = 0.004 | 0.13 (−0.026, 0.277) p = 0.062 |
Adjusted geometric mean ratio to baseline | |||||
Trough IC (l) | 1.13 | 1.04 | 1.08 | 1.08 (1.019, 1.150) p = 0.004 | 1.05 (0.982, 1.112) p = 0.109 |
Trough RV (l) | 0.90 | 0.96 | 0.92 | 0.93 (0.875, 0.991) p = 0.011 | 0.98 (0.919, 1.044) p = 0.459 |
Trough TLC (l) | 1.00 | 1.00 | 1.00 | 1.00 (0.980, 1.026) p = 0.776 | 1.00 (0.981, 1.027) p = 0.721 |
IC, Inspiratory capacity; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; RV, residual volume; SFC, salmeterol/fluticasone propionate combination; TIO, tiotropium; TLC, total lung capacity.