No of exacerbations during the 1-year study | Tiotropium + placebo(N = 156 patients) | Tiotropium + fluticasone/salmeterol(N = 145 patients) |
0 | 37.2% | 40.0% |
1 | 28.8% | 23.4% |
2 | 13.5% | 17.9% |
3 | 9.6% | 10.3% |
4 | 2.6% | 3.4% |
5 | 4.5% | 3.4% |
6 | 2.6% | 1.4% |
7 | 0.6% | 0.0% |
8 | 0.6% | 0.0% |
Total no of adjudicated exacerbations | 222 | 188 |
Range | 0–8 | 0–6 |
Total person-years of follow-up | 138.0 | 137.0 |
Weighted mean adjudicated exacerbation rate per patient-year | 1.61 | 1.37 |