Table 3 Weighted meta-regression of the effects of methodological quality on diagnostic precision of pleural tumour markers

	Number of studies	Coefficient	RDOR (95% CI)	p Value
CA 125 studies	10
STARD ⩾13	5	1.855	6.39 (0.01 to 2909.97)	0.487
QUADAS ⩾10	6	−1.715	0.18 (0.00 to 70.15)	0.508
CA 13-5 studies	11
STARD ⩾13	8	1.857	6.40 (0.77 to 52.92)	0.076
QUADAS ⩾10	8	−0.783	0.46 (0.06 to 3.50)	0.393
CA 19-9 studies	7
STARD ⩾13	4	−2.402	0.09 (0.00 to 556.75)	0.445
QUADAS ⩾10	4	0.397	1.49 (0.00 to 720.09)	0.851
CYFRA 21-1 studies	18
STARD ⩾13	9	−0.262	0.77 (0.23 to 2.59)	0.650
QUADAS ⩾10	10	0.075	1.08 (0.33 to 3.55)	0.894

RDOR, relative diagnostic odds ratio; CI, confidence interval; STARD, standards for reporting diagnostic accuracy; QUADAS, quality assessment for studies of diagnostic accuracy.