| Primary pleural tumours | |
| Angiosarcoma | CD34, CD31, FVIIIRA |
| Epithelioid haemangioendothelioma | CD34, CD31, FVIIIRA |
| Synovial sarcoma | Cytokeratins, CD99, bcl-2, cytogenetics |
| Sarcomas (various) | Various depending on type |
| Localised malignant mesothelioma | None |
| Solitary fibrous tumour | CD34, bcl-2, CD99 |
| Well-differentiated papillary mesothelioma | None (needs macroscopic appearance and usually peritoneum) |
| Adenomatoid tumour | None (needs macroscopic appearance) |
| Calcifying tumour of the pleura | None (usually young patient) |
| Desmoplastic small round cell tumour | Cytokeratins, desmin, EMA, WT-1, NSE |
| Thymic tumours | Cytokeratins, EMA, occasionally CD5 |
| Lymphoma | Lymphoid markers |
| |
| Metastatic tumours | |
| Carcinomas | Cytokeratins |
| Sarcomas | Various depending on type |
| Lymphomas | Lymphoid markers |
| Malignant melanoma | S-100, HMB45, melan-A |
| Thymic tumours | Cytokeratins, EMA, occasionally CD5 |
| |
| Non-neoplastic mimics | |
| Pleural fibrosis | Rarely cytokeratins |
| Reactive mesothelial cells | Desmin, EMA, p53 |