Epithelioid mesothelioma | Adenocarcinoma | |
Histochemistry | ||
PAS | + (glycogen) | + (small amount of glycogen with mucin) |
plus diastase | – (almost always) | + |
Alcian blue | May be + | |
plus hyaluronidase | + | Usually still + |
Immunohistochemistry | – | |
Calretinin | + | – |
CK5/6 | + | – |
WT-1 | + | – |
Thrombomodulin | + | – |
HBME-1 | + | – |
N-cadherin | + | – |
CEA | – | + |
MOC-31 | – | + |
Ber EP4 | – | + |
B72.3 | – | + |
LeuM1 (CD15) | – | + |
E-cadherin | – | + |
Lewisy (BG8) | – | + |
TTF-1 | – | + (lung and thyroid) |
Others | Either | Or |
Note that all may give aberrant or unexpected results occasionally and need to be assessed in combination, and also that adenocarcinomas from non-pulmonary sites may show different expression (for sensitivities and specificities see King et al53 and Ordonez54).