Associations between infection counts by age 5 and outcomes at age 8: cohort children
| No of infections | Atopy at age 8 (n = 490) | Current wheeze at age 8 (n = 523) | Seasonal rhinitis at age 8 (n = 523) | ||||
|---|---|---|---|---|---|---|---|
| OR* (95% CI) | p Value | OR* (95% CI) | p Value | OR* (95% CI) | p Value | ||
| *Adjusted for maternal atopy, paternal atopy, birth order and current exposure to cigarette smoke. | |||||||
| Total infections age 0–5 | 9526 | 1.01 (0.99 to 1.03) | 0.28 | 1.05 (1.03 to 1.08) | <0.001 | 1.05 (1.03 to 1.07) | <0.001 |
| Total infections age 0–1 | 2673 | 0.99 (0.92 to 1.05) | 0.65 | 1.09 (1.02 to 1.17) | 0.01 | 1.06 (1.00 to 1.13) | 0.04 |
| Total infections age 1–2 | 2456 | 0.99 (0.93 to 1.06) | 0.84 | 1.10 (1.02 to 1.18) | 0.01 | 1.10 (1.04 to 1.17) | 0.002 |
| Total infections age 2–3 | 1934 | 1.07 (0.99 to 1.15) | 0.08 | 1.11 (1.02 to 1.21) | 0.02 | 1.12 (1.05 to 1.21) | 0.001 |
| Total infections age 3–4 | 1439 | 1.06 (0.97 to 1.16) | 0.18 | 1.20 (1.09 to 1.31) | <0.001 | 1.24 (1.14 to 1.35) | <0.001 |
| Total infections age 4–5 | 1122 | 1.11 (1.01 to 1.23) | 0.03 | 1.26 (1.13 to 1.39) | <0.001 | 1.21 (1.10 to 1.32) | <0.001 |
| Infection type (age 0–5) | |||||||
| Lower respiratory | 3364 | 1.03 (0.99 to 1.07) | 0.20 | 1.14 (1.09 to 1.20) | <0.001 | 1.09 (1.05 to 1.14) | <0.001 |
| Upper respiratory | 3006 | 0.99 (0.93 to 1.06) | 0.86 | 1.05 (0.99 to 1.12) | 0.13 | 1.09 (1.03 to 1.15) | 0.003 |
| Ear | 1462 | 1.03 (0.95 to 1.12) | 0.49 | 1.07 (0.98 to 1.18) | 0.16 | 1.16 (1.07 to 1.25) | <0.001 |
| Eye | 753 | 1.07 (0.92 to 1.23) | 0.40 | 1.17 (1.00 to 1.37) | 0.06 | 1.09 (0.95 to 1.25) | 0.23 |
| Gastrointestinal | 695 | 1.13 (0.96 to 1.33) | 0.14 | 1.23 (1.03 to 1.47) | 0.03 | 1.36 (1.17 to 1.58) | <0.001 |
| Urinary tract | 132 | 0.79 (0.52 to 1.19) | 0.23 | 0.78 (0.49 to 1.25) | 0.27 | 1.01 (0.73 to 1.39) | 0.96 |
| Skin | 114 | 1.30 (0.89 to 1.91) | 0.18 | 0.79 (0.45 to 1.39) | 0.39 | 1.03 (0.69 to 1.54) | 0.87 |