Effect of peptide inhalation on lymphocyte, macrophage, eosinophil, neutrophil, basophil and mast cell counts in bronchial biopsy specimens from responders and non-responders
| Cell markers | Responders (R) | Non-responders (NR) | p Value(R vs NR) | ||||
|---|---|---|---|---|---|---|---|
| Diluent | Peptide | p Value | Diluent | Peptide | p Value | ||
| The results are expressed as the number of positive cells (median and range) per mm2 beneath the basement membrane. Statistical comparisons of diluent and peptide inhalation (within-group comparisons) were performed using two-tailed Wilcoxon signed rank tests. Between-group comparisons of the change from diluent to peptide in responders and non-responders were performed using the non-parametric Mann-Whitney test. | |||||||
| CD3 | 64 (29.3–198.0) | 96 (40.0–236.0) | 0.05 | 86.7 (34.4–218) | 55.5 (34.7–116) | 0.03 | 0.005 |
| CD4 | 36.6 (14.0–101.3) | 58.9 (16.0–129.3) | 0.03 | 53.4 (15.2–93.3) | 31.6 (8.0–85.0) | 0.09 | 0.006 |
| CD8 | 34.2 (18.9–72.0) | 38.7 (18.7–72.0) | 0.85 | 47.2 (10.0–87.0) | 38.2 (13.3–69.3) | 0.23 | 0.54 |
| CD25 | 38.7 (14.7–96.0) | 46.7 (12.0–88.0) | 0.38 | 41.3 (11.2–84.0) | 40.7 (12.0–84.0) | 1.03 | 0.6 |
| CD68+ macrophages | 28.1 (15.3–62.0) | 28.1 (9.8–67.0) | 0.85 | 35 (16.0–84.0) | 34.6 (5.6–66.7) | 0.68 | 0.58 |
| MBP+ eosinophils | 29 (18.4–61.3) | 40.2 (18.4–160.0) | 0.07 | 33.3 (14.0–52.0) | 20.3 (12.8–81.6) | 0.79 | 0.09 |
| Elastase+ neutrophils | 44.4 (20.5–98.0) | 60.7 (32.0–108.0) | 0.11 | 47.3 (22.4–72.0) | 37.7 (28.7–68.0) | 0.38 | 0.05 |
| BB1+ basophils | 53 (18.5–94.0) | 45.1 (18.7–128.0) | 0.73 | 39.3 (20.6–100.0) | 59.8 (20.0–94.0) | 0.2 | 0.31 |
| Tryptase+ mast cells | 45.8 (22.0–72.0) | 49 (22.7–84.0) | 0.73 | 41.6 (22.5–76.0) | 41 (20.0–66.0) | 0.62 | 0.75 |