Table 3

Statistical comparison of biomarkers in patients with COPD and controls

Sequence	Protein ID	Controls		COPD patients		T ratio	FDR_p	p Value
Sequence	Protein ID	Mean	SD	Mean	SD	T ratio	FDR_p	p Value
The protein markers were filtered by false discovery adjusted p-value (FDR_p) of 0.015. The FDR adjusted p value (sometimes called just FDR) is a practical way of dealing with multiple testing issues and can be interpreted as estimated proportion of false positives in the list. The T ratio was computed from common log scale. The names of all the analytes are given in the online supplement available at http://thorax.bmj.com/supplemental.
1	MMP-9	4129.05	1524.12	6298.61	2437.93	5.07	0.00028	0.00000
2	Eotaxin-2	3821.17	2786.26	6897.35	4303.97	4.37	0.00078	0.00003
3	MMP-7	860.72	340.62	1431.51	1021.53	4.37	0.00078	0.00003
4	MMP-10	1111.17	445.91	1813.39	1424.64	4.54	0.00078	0.00002
5	TARC	178.84	124.23	386.29	541.28	4.44	0.00078	0.00002
6	TNF-α	83.24	19.97	112.99	48.21	4.40	0.00078	0.00003
7	BDNF	293.34	347.45	992.07	1348.16	4.17	0.00106	0.00007
8	GCP-2	100.41	26.19	131.26	45.91	4.16	0.00106	0.00007
9	MIF	702.08	165.77	1062.19	931.81	4.15	0.00106	0.00007
10	NE	3951.64	925.28	4917.56	1284.20	4.18	0.00106	0.00006
11	IL-1-sR1	173.18	89.25	264.36	157.92	4.04	0.00144	0.00011
12	MMP-8	7479.60	5112.69	14511.88	9305.13	4.00	0.00151	0.00013
13	TIMP-1	2885.88	1477.78	4677.85	2424.25	3.91	0.00197	0.00018
14	AR	117.76	30.93	146.85	47.46	3.77	0.00253	0.00029
15	IL-10rβ	689.21	200.70	874.60	287.25	3.70	0.00253	0.00037
16	IL-12p40	130.59	41.13	162.29	54.10	3.69	0.00253	0.00037
17	IL-1rα	176.72	53.05	221.43	61.74	3.80	0.00253	0.00026
18	IL-2rβ	275.40	92.33	366.01	155.99	3.73	0.00253	0.00033
19	IL-8	209.52	80.41	278.40	101.25	3.79	0.00253	0.00027
20	I-TAC	86.84	51.75	138.41	95.26	3.71	0.00253	0.00036
21	VEGF	127.21	40.98	168.05	65.40	3.70	0.00253	0.00036
22	VEGF-D	263.56	142.27	361.02	186.09	3.56	0.00377	0.00058
23	CD30	158.85	69.99	210.88	102.48	3.48	0.00457	0.00077
24	Eotaxin	235.07	80.48	282.00	65.23	3.49	0.00457	0.00075
25	MCP-1	633.02	303.92	936.95	584.67	3.44	0.00496	0.00087
26	IL-1α	91.98	31.06	113.74	38.44	3.41	0.00508	0.00096
27	Prolactin	925.25	244.88	1274.07	838.37	3.42	0.00508	0.00093
28	TNF-R1	525.09	455.95	800.09	616.36	3.35	0.00597	0.00117
29	IL-1β	98.21	34.65	124.21	53.06	3.31	0.00662	0.00134
30	BLC	192.76	89.61	294.84	240.72	3.29	0.00675	0.00142
31	FGF-4	347.42	95.24	434.21	169.61	3.26	0.00719	0.00156
32	MPIF-1	624.64	331.03	825.75	398.73	3.17	0.00932	0.00209
33	IGFBP-4	6118.33	1188.73	7136.63	2703.80	3.15	0.00962	0.00222
34	CTACK	3480.02	1367.85	4745.23	3090.78	3.12	0.01005	0.00239
35	HCC-1	1201.77	352.24	1549.81	870.31	3.07	0.01130	0.00276
36	Eotaxin-3	229.35	114.73	609.19	2006.73	3.06	0.01138	0.00291
37	IL-17	343.13	69.30	390.90	84.96	3.05	0.01138	0.00302
38	TGF-α	210.31	107.82	595.09	2168.58	3.05	0.01138	0.00299
39	MIP-1δ	2094.72	836.45	2878.11	1762.62	2.99	0.01326	0.00362
40	EGF	158.28	64.86	216.59	164.16	2.93	0.01458	0.00428
41	M-CSF	78.34	24.86	96.89	35.82	2.93	0.01458	0.00422
42	Protein C	8112.46	1788.08	9087.41	1603.96	2.94	0.01458	0.00412
43	HCC-4	8572.51	2501.97	10071.78	2581.08	2.90	0.01498	0.00461