Biochemical surfactant properties and gas exchange in healthy controls and patients with acute respiratory distress syndrome (ARDS) receiving either standard care or additional surfactant treatment
| Control | ARDS | |||||
|---|---|---|---|---|---|---|
| Baseline | Standard care | Surfactant treatment | ||||
| +48 h | +120 h | +48 h | +120 h | |||
| Data are presented as median (25–75th percentile). | ||||||
| LA, large surfactant aggregate fraction; PL, phospholipids; PC, phosphatidylcholine; PG, phosphatidylglycerol; SP-C, surfactant protein C; Pao2/Fio2, arterial oxygen tension/fractional oxygen inspiration. | ||||||
| Data are given for healthy controls and for patients with ARDS before (baseline; −3 h), 48 h and 120 h after intrabronchial administration of recombinant SP-C-based surfactant (n = 14) and for patients with ARDS receiving standard care only (n = 17). Biochemical data are given for the total lavage fluid. The baseline Pao2/Fio2 value represents the mean of three readings over the 6 h baseline period. | ||||||
| *p<0.05; **p<0.01; ***p<0.001 pre-treatment vs post-treatment. | ||||||
| LA (% of PL) | 79.1 (70.5–86.5) | 45.4 (28.8–53.2) | 27.4 (23.2–52.2) | 30.5 (25.8–31.10) | 73.5 (68.3–77.2)** | 64.2 (55.3–75.2) |
| PL (µg/ml) | 23.5 (17.2–29.8) | 25.6 (14.5–44.6) | 30.4 (15.2–42.1) | 17.0 (9.6–25.4) | 185.0 (44.8–230.0)** | 48.4 (31.6–78.1) |
| PC (% of total PL) | 80.0 (79.0–82.3) | 77.9 (70.3–81.6) | 81.1 (73.2–83.1) | 81.9 (80.6–85.3) | 77.6 (68.1–83.5) | 72.9 (66.6–78.1) |
| PG (% of total PL) | 11.8 (11.3–12.7) | 1.6 (1.2–2.6) | 1.9 (0.7–5.5) | 2.1 (0.8–2.3) | 15.7 (8.9–21.8)** | 6.8 (5.3–13.7)* |
| Palmitic acid (% of PC fatty acids) | 74.2 (71.4–77.1) | 53.6 (44.8–59.2) | 52.6 (50.3–57.4) | 57.8 (56.3–59.2) | 85.6 (77.8–89.4)** | 84.1 (78.5–84.2)** |
| SP-C (ng/ml) | 494.9 (397.0–601.0) | 350.2 (216.4–724.3) | 437.0 (250.0–657.0) | 436.0 (284.0–760.0) | 1970.0 (770.0–2490.0)** | 717.0 (290.0–1160.0) |
| Pao2/Fio2 (mm Hg) | 461.0 (446.0–469.0) | 126.5 (103–149.7) | 134.0 (94.1–164.0) | 156.0 (85.0–215.0) | 143.0 (138.0–182.0)** | 212.0 (156.0–250.0)*** |