Univariable and multivariable predictors for forced expiratory volume in 1 s (FEV1, % predicted) in the overall cohort, index subjects and non-index subjects
| Overall | Index | Non-index | |||||
|---|---|---|---|---|---|---|---|
| Beta (95% CI) | p Value | Beta (95% CI) | p Value | Beta (95% CI) | p Value | ||
| *Univariate model includes sex (male = 1, female = 0), pack-years of cigarettes, ever-smoking (yes = 1, no = 0), asthma (yes = 1, no = 0), pneumonia (yes = 1, no = 0), chronic bronchitis (yes = 1, no = 0), index case (yes = 1, no = 0) | |||||||
| †Multivariate model includes sex (male = 1, female = 0), pack-years of cigarettes, ever-smoking (yes = 1, no = 0), asthma (yes = 1, no = 0), pneumonia (yes = 1, no = 0), chronic bronchitis (yes = 1, no = 0), index case (yes = 1, no = 0). | |||||||
| ‡Odds ratio estimate for pack-years is for each pack-year smoked. | |||||||
| Univariable predictors | |||||||
| Sex | −19.69 (−13.17 to −26.21) | <0.0001 | −11.30 (−20.53 to −2.06) | 0.02 | −23.49 (−31.36 to−15.63) | <0.001 | |
| Pack-years‡ | −1.10 (−0.13 to −0.89) | <0.0001 | −0.72 (−0.98 to −0.46) | <0.0001 | −1.19 (−1.49 to −0.89) | <0.0001 | |
| Ever smoking | −29.26 (−35.58 to −22.94) | <0.0001 | −25.31 (−35.32 to −15.30) | <0.0001 | −24.64 (−32.42 to −16.86) | <0.0001 | |
| Asthma | −19.08 (−25.87 to −12.30) | <0.0001 | −7.46 (−16.83 to 1.92) | 0.12 | −21.14 (−29.77 to −12.52) | <0.0001 | |
| Pneumonia | −21.25 (−27.70 to −14.70) | <0.0001 | −17.33 (−26.99 to −7.68) | 0.0005 | −18.09 (−26.15 to −10.02) | <0.0001 | |
| Chronic bronchitis | −17.264 (−25.28 to −9.25) | <0.0001 | −4.67 (−15.83 to 6.31) | 0.40 | −23.83 (−33.64 to −14.03) | <0.0001 | |
| Index | −26.34 (−32.74 to −19.73) | <0.0001 | – | – | – | – | |
| Multivariable predictors† | |||||||
| Sex | −15.51 (−20.58 to −10.43) | <0.0001 | −8.57 (−16.63 to −0.52) | 0.04 | −19.53 (−26.10 to −12.96) | <0.0001 | |
| Pack-years‡ | −0.62 (−0.84 to −0.40) | <0.0001 | −0.51 (−0.80 to −0.22) | 0.0007 | −0.67 (−1.01 to −0.32) | 0.0002 | |
| Ever smoking | −10.36 (−16.86 to −3.85) | 0.002 | −13.33 (−24.34 to −2.33) | 0.02 | −8.62 (−17.04 to −0.20) | 0.04 | |
| Asthma | −12.47 (−17.79 to −7.15) | <0.0001 | −7.33 (−15.49 to 0.83) | 0.08 | −15.00 (−22.09 to −7.90) | <0.0001 | |
| Pneumonia | −14.38 (−19.51 to −9.25) | <0.0001 | −14.63 (−23.11 to −6.15) | 0.0009 | −14.49 (−20.98 to −8.00) | <0.0001 | |
| Chronic bronchitis | −9.26 (−15.35 to −3.16) | 0.003 | −5.24 (−14.70 to 4.22) | 0.28 | −11.34 (−19.43 to −3.26) | 0.006 | |
| Index | −15.19 (−20.54 to −9.84) | <0.0001 | – | – | |||