Baseline characteristics of study population
| Non-OSAS(n = 30) | Mild to moderate OSAS(n = 35) | Severe BMI-matched OSAS(n = 31) | Severe obese OSAS(n = 14) | |
|---|---|---|---|---|
| Values represent mean (SD) or median (interquartile range) depending on the distribution. | ||||
| BMI, body mass index; BP, blood pressure; ESS, Epworth Sleepiness Scale; AHI, apnoea/hypopnoea index; DI, desaturation index; Sao2, oxygen saturation; TST, total sleep time. | ||||
| *p<0.05 vs non-OSAS. | ||||
| †p<0.05 vs mild to moderate OSAS. | ||||
| ‡p<0.05 vs severe BMI-matched OSAS. | ||||
| Age | 41 (6) | 42 (8) | 43 (9) | 39 (9) |
| BMI (kg/m2) | 30.7 (3.1) | 32.9 (6.03) | 32.1 (3.5) | 42.5 (4.8)*†‡ |
| Neck size (cm) | 43.1 (1.8) | 44.6 (2.9) | 44.1 (2.7) | 48.1 (3.0)*†‡ |
| Current smokers | 9 (30%) | 13 (37%) | 12 (39%) | 4 (29%) |
| Total cholesterol(mmol/l) | 5.3 (0.8) | 5.2 (0.8) | 5.3 (0.8) | 5.2 (1.0) |
| HDL-cholesterol(mmol/l) | 1.02 (0.25) | 1.03 (0.21) | 1.00 (0.18) | 0.92 (0.18) |
| LDL-cholesterol(mmol/l) | 3.57 (0.72) | 3.29 (0.67) | 3.47 (0.73) | 3.34 (0.91) |
| Triglyceride (mmol/l) | 1.45 (0.74) | 1.96 (1.1)* | 1.91 (0.9)* | 2.00 (0.87)* |
| BP (mm Hg) | 131/82 (18/9) | 128/81 (13/7) | 135/86 (18/12) | 139/84 (15/9) |
| Folate (μg/l) | 7.9 (6.3–11.8) | 7.5 (5.9–12.2) | 8.3 (5.8–10.3) | 7.6 (4.3–13.4) |
| Vitamin B12 (ng/l) | 339 (262–421) | 377 (305–481) | 395 (325–548) | 319 (262–372) |
| ESS | 6 (5–14) | 12 (6–16) | 16 (12–19)*† | 14 (9–18)* |
| AHI | 1.1 (0.4–1.9) | 14.0 (9.0–21.9)* | 50.9 (37.1–73.2)*† | 74.1 (67.3–98.3)*†‡ |
| DI | 1.5 (0.0–3.0) | 13 (8–22)* | 49 (34–71)*† | 69 (55–80)*†‡ |
| Basal Sao2 | 93.8 (92.8–95.5) | 93.8 (92.8–94.4) | 92.6 (90.5–94.7)* | 89.8 (86.7–92.7)*†‡ |
| Min Sao2 | 88.9 (87.2–90.8) | 84.7 (81.4–86.9)* | 77.5 (67.7–81.5)*† | 66.9 (57.5–77.8)*†‡ |
| %TST <90% | 0 (0–0) | 1 (0–6)* | 15 (4–45)*† | 31 (12–80)*† |