Baseline body composition, pseudouridine, functional status and inflammatory status of the participants
| Healthy n = 18 | Patients n = 40 | p Value | |
|---|---|---|---|
| BMI, body mass index; FFM, fat-free mass; FM, fat mass; IL, interleukin; PSU, pseudouridine; sTNFα R, soluble tumour necrosis factor α receptor; TNF, tumour necrosis factor. | |||
| Values are presented as mean (SD). The p value represents the difference between patients and healthy participants. | |||
| *Geometric mean. | |||
| BMI (kg/m2) | 25.8 (2.9) | 22.4 (3.8) | <0.001 |
| FFM (kg) | 61.9 (11.3) | 46 (7.7) | <0.001 |
| FM (kg) | 16.1 (7.9) | 18.8 (7.1) | 0.2 |
| PSU * (µmol/mmol creatinine) | 35.89 (1.19) | 44.48 (1.35) | <0.001 |
| PSU/FFM * (µmol/mmol creatinine/kg FFM) | 0.59 (1.38) | 0.98 (1.5) | <0.001 |
| Quadriceps Force, (Nm) | 121.3 (37.0) | 77.2 (36.3) | <0.001 |
| Handgrip force (kg) | 41.7 (11) | 33.7 (9.6) | 0.006 |
| Peak workload max (W) | 216 (57.5) | 61.3 (25.2) | <0.001 |
| IL6* (pg/ml) | 1.71 (1.7) | 4.03 (1.9) | <0.001 |
| TNFα* (pg/ml) | 1.22 (1.37) | 1.28 (1.46) | 0.64 |
| sTNFα R55* (ng/ml) | 1.14 (1.26) | 1.31 (1.45) | 0.28 |
| sTNFα R75* (ng/ml) | 1.14 (1.27) | 1.49 (1.39) | 0.004 |