Operating characteristics of CURB65, CRB65, systemic inflammatory response syndrome criteria used in four different ways and standardised early warning score
| Severity | Mortality | Sensitivity % | Specificity % | PPV % | NPV % |
|---|---|---|---|---|---|
| NC, not calculable; NPV, negative predictive value; PPV, positive predictive value; SEWS, standardised early warning score; SIRS, systemic inflammatory response syndrome. | |||||
| *Defined as in table 1. | |||||
| †Defined by the presence or absence of: temperature <36°C or >38°C, pulse >90/min, respiratory rate >20/min and white cell count <4 or >12 cells/mm3. | |||||
| ‡Defined by above and definition of severe sepsis/septic shock given in table 1. | |||||
| §New definition (see Results section). | |||||
| CURB65 | |||||
| CURB65 = 0 | 0/58 (0%) | 100 | 0 | 19 | NC |
| CURB65 = 1 | 3/82 (4%) | 100 | 17 | 22 | 100 |
| CURB65 = 2 | 20/119 (17%) | 96 | 40 | 27 | 98 |
| CURB65 = 3 | 27/105 (26%) | 71 | 69 | 35 | 91 |
| CURB65 = 4 | 27/49 (55%) | 37 | 92 | 53 | 86 |
| CURB65 = 5 | 2/6 (33%) | 2.5 | 99 | 33 | 81 |
| CRB65 | |||||
| CRB65 = 0 | 0/71 (0%) | 100 | 0 | 19 | NC |
| CRB65 = 1 | 21/150 (14%) | 100 | 21 | 23 | 100 |
| CRB65 = 2 | 28/131 (21%) | 73 | 59 | 29 | 90.5 |
| CRB65 = 3 | 28/61 (46%) | 38 | 89 | 45 | 86 |
| CRB65 = 4 | 2/6 (33%) | 2.5 | 99 | 33 | 81 |
| SIRS used in four different ways | |||||
| No SIRS* | 21/124 (17%) | 100 | 0 | 19 | NC |
| SIRS | 21/197 (11%) | 73 | 30 | 20 | 83 |
| Severe sepsis/septic shock | 37/98 (38%) | 47 | 82 | 38 | 87 |
| SIRS = 0† | 5/35 (14%) | 100 | 0 | 19 | NC |
| SIRS = 1 | 16/89 (18%) | 94 | 9 | 19 | 86 |
| SIRS = 2 | 28/136 (21%) | 73 | 30 | 20 | 83 |
| SIRS = 3 | 27/113 (24%) | 38 | 62 | 19 | 81 |
| SIRS = 4 | 3/46 (6%) | 4 | 87 | 6 | 80 |
| SIRS = 0‡ | 5/35 (14%) | 100 | 0 | 19 | NC |
| SIRS = 1 | 16/89 (18%) | 94 | 9 | 19 | 86 |
| SIRS = 2 | 12/89 (13%) | 73 | 30 | 20 | 83 |
| SIRS = 3 | 8/75 (11%) | 58 | 53 | 22 | 84 |
| SIRS = 4 | 1/33 (3%) | 48 | 73 | 29 | 86 |
| Severe sepsis/septic shock | 37/98 (38%) | 47 | 82 | 38 | 87 |
| No SIRS or hypotension/organ hypo-perfusion§ | 9/81 (11%) | 100 | 0 | 19 | NC |
| SIRS | 21/197 (11%) | 89 | 21 | 21 | 89 |
| Hypotension and/or organ hypo-perfusion, but no SIRS | 12/43 (28%) | 62 | 73 | 35 | 89 |
| Severe sepsis/septic shock | 37/98 (38%) | 47 | 82 | 38 | 87 |
| SEWS | |||||
| SEWS = 0 | 4/41 (10%) | 100 | 0 | 19 | NC |
| SEWS = 1 | 5/58 (9%) | 95 | 11 | 20 | 90 |
| SEWS = 2 | 17/87 (19.5%) | 89 | 26 | 22 | 91 |
| SEWS = 3 | 12/80 (15%) | 67 | 47 | 23 | 86 |
| SEWS = 4 | 10/57 (17.5%) | 52 | 67 | 27 | 86 |
| SEWS = 5 | 8/34 (23.5%) | 39 | 81 | 32 | 85 |
| SEWS ⩾6 | 23/62 (37%) | 29 | 88 | 38 | 84 |