Biallelic results for four markers of iNOS testing null hypotheses of no linkage and no association (family based association test, additive model) in 230 Indian families with probands with asthma
| Allele | Repeat size | Allele frequency | Informative families (n) | z Score | p Value* |
|---|---|---|---|---|---|
| *p Values are nominal and not corrected for the multiple testing. | |||||
| −2.5 kb CCTTT repeat (M1) | |||||
| 1 (176 bp) | 9 | 0.042 | 32 | 0.926 | 0.355 |
| 2 (181 bp) | 10 | 0.166 | 92 | –0.612 | 0.541 |
| 3 (186 bp) | 11 | 0.162 | 89 | 0.476 | 0.634 |
| 4 (191 bp) | 12 | 0.192 | 108 | –1.273 | 0.203 |
| 5 (196 bp) | 13 | 0.153 | 96 | 0.219 | 0.827 |
| 6 (201 bp) | 14 | 0.132 | 80 | 0.722 | 0.470 |
| 7 (206 bp) | 15 | 0.107 | 61 | 0.663 | 0.508 |
| 8 (211 bp) | 16 | 0.022 | 19 | –0.539 | 0.590 |
| 9 (216 bp) | 17 | 0.012 | 10 | 0.577 | 0.564 |
| 10 (221 bp) | 18 | 0.005 | 2 | – | – |
| Intron 2 GT repeat (M2) | |||||
| 1 (215 bp) | 19 | 0.032 | 24 | –1.095 | 0.273 |
| 2 (217 bp) | 20 | 0.146 | 70 | –0.826 | 0.409 |
| 3 (219 bp) | 21 | 0.522 | 149 | 2.288 | 0.022 |
| 4 (221 bp) | 22 | 0.245 | 104 | –1.422 | 0.155 |
| 5 (223 bp) | 23 | 0.03 | 19 | –0.888 | 0.374 |
| 6 (225 bp) | 24 | 0.014 | 10 | 0.302 | 0.763 |
| 7 (229 bp) | 26 | 0.011 | 2 | – | – |
| Intron 4 GT repeat (M3) | |||||
| 1 (343 bp) | 13 | 0.213 | 89 | –0.926 | 0.354 |
| 2 (345 bp) | 14 | 0.007 | 7 | – | – |
| 3 (347 bp) | 15 | 0.406 | 142 | 2.759 | 0.006 |
| 4 (349 bp) | 16 | 0.166 | 82 | –0.403 | 0.687 |
| 5 (351 bp) | 17 | 0.011 | 9 | – | – |
| 6 (353 bp) | 18 | 0.154 | 88 | –2.001 | 0.045 |
| 7 (355 bp) | 19 | 0.026 | 15 | 0.19 | 0.849 |
| 8 (357 bp) | 20 | 0.016 | 10 | –0.632 | 0.527 |
| 9 (339 bp) | 11 | 0.002 | 1 | – | – |
| Intron 5 CA repeat (M4) | |||||
| 1 (323 bp) | 14 | 0.238 | 65 | 1.73 | 0.08 |
| 2 (325 bp) | 15 | 0.144 | 60 | –1.91 | 0.06 |
| 3 (327 bp) | 16 | 0.207 | 69 | –1.33 | 0.18 |
| 4 (329 bp) | 17 | 0.087 | 28 | –0.82 | 0.41 |
| 5 (331 bp) | 18 | 0.013 | 8 | – | – |
| 6 (333 bp) | 19 | 0.027 | 11 | 2.32 | 0.02 |
| 7 (335 bp) | 20 | 0.046 | 19 | 2.12 | 0.03 |
| 8 (337 bp) | 21 | 0.059 | 30 | –0.26 | 0.79 |
| 9 (339 bp) | 22 | 0.148 | 66 | 0.40 | 0.69 |
| 10 (341 bp) | 23 | 0.029 | 10 | –1.27 | 0.21 |
| 11 (343 bp) | 24 | 0.003 | 1 | — | — |