Pooled values* (95% confidence intervals) of diagnostic odds ratio (DOR), sensitivity, and specificity of five commercial nucleic acid amplification tests (NAATs)
| Test | NAA method | AFB+ | AFB− | ||||
|---|---|---|---|---|---|---|---|
| DOR | Sensitivity | Specificity | DOR | Sensitivity | Specificity | ||
| PCR, polymerase chain reaction; SDA, strand displacement amplification; TMA, trascription mediated amplification; LCR, ligase chain reaction; DOR, diagnostic odds ratio. | |||||||
| *Random effect model. | |||||||
| Amplicor | PCR | 117 (56 to 246) | 0.96 (0.94 to 0.97) | 0.83 (0.8 to 0.86) | 77 (51 to 115) | 0.61 (0.57 to 0.65) | 0.97 (0.968 to 0.974) |
| Cobas Amplicor | PCR | 99 (56 to 173) | 0.96 (0.95 to 0.97) | 0.74 (0.68 to 0.8) | 220 (144 to 335) | 0.64 (0.59 to 0.69) | 0.993 (0.992 to 0,994) |
| BDP | SDA | 181 (39 to 834) | 0.98 (0.96 to 0.99) | 0.89 (0.84 to 0.93) | 96 (53 to 175) | 0.71 (0.66 to 0.76) | 0.97 (0.964 to 0.974) |
| E-MTD | TMA | 314 (99 to 995) | 0.97 (0.95 to 0.98) | 0.96 (0.93 to 0.97) | 157 (48 to 510) | 0.76 (0.7 to 0.8) | 0.97 (0.966 to 0.974) |
| LCx | LCR | 42 (12 to 142) | 0.96 (0.94 to 0.98) | 0.71 (0.64 to 0.78) | 71 (38 to 132) | 0.57 (0.5 to 0.64) | 0.98 (0.978 to 0.985) |