Table 3

Genome-wide linkage analysis for bronchodilator responsiveness in all subjects, non-smokers and smokers only

Phenotype*	Subjects	Covariates	Chromosome	cM	LOD	p Value
The maximum LOD score for each analysis is reported. Full results are available in supplementary table 3.
*Definitions of BDR phenotypes⁷:
BDRbase = (FEV_{1post-bronchodilator}-FEV_{1pre-bronchodilator})/FEV_{1pre-bronchodilator} ×100%.
BDRpred = (FEV_{1post-bronchodilator}-FEV_{1pre-bronchodilator})/FEV_1predicted ×100%.
BDRabs = (FEV_{1post-bronchodilator}-FEV_{1pre-bronchodilator}).
All three BDR variables were log₁₀ transformed for analysis.
BDRbase	All	None	4	70	1.26	0.008
	Non-smokers	None	10	31	1.59	0.002
	Smokers	Gender	16	66	1.31	0.019
BDRpred	All	None	9	49	1.25	0.007
	Non-smokers	None	10	31	1.69	0.002
	Smokers	Gender	16	66	1.22	0.018
BDRabs	All	None	9	49	1.53	0.003
	Non-smokers	None	9	49	1.72	<0.001
	Smokers	Gender	16	66	1.60	0.012