| EPHX1 metabolic phenotypes by asthma phenotypes | GSTP1 Ile105Val | p Value‡ | |||||
| Ile/Ile | Ile/Val | Val/Val | |||||
| N* | OR† (95% CI) | N* | OR† (95% CI) | N* | OR† (95% CI) | ||
| Lifetime asthma | |||||||
| Low/intermediate | 842/135 | 1.0 | 1012/181 | 1.0 | 297/42 | 1.0 | |
| High | 201/36 | 1.12 (0.74 to 1.70) | 217/49 | 1.34 (0.92 to 1.94) | 46/23 | 4.01 (1.97 to 8.16) | 0.006 |
| Current asthma | |||||||
| Low/intermediate | 842/94 | 1.0 | 1012/114 | 1.0 | 297/24 | 1.0 | |
| High | 201/22 | 1.15 (0.67 to 2.00) | 217/32 | 1.31 (0.80 to 2.13) | 46/14 | 4.42 (1.65 to 11.83) | 0.03 |
| Early persistent asthma | |||||||
| Low/intermediate | 842/49 | 1.0 | 1012/66 | 1.0 | 297/19 | 1.0 | |
| High | 201/8 | 0.65 (0.29 to 1.43) | 217/19 | 1.55 (0.87 to 2.76) | 46/10 | 3.89 (1.32 to 11.43) | 0.02 |
| Late onset asthma | |||||||
| Low/intermediate | 842/67 | 1.0 | 1012/92 | 1.0 | 297/16 | 1.0 | |
| High | 201/26 | 1.65 (0.99 to 2.75) | 217/24 | 1.28 (0.78 to 2.11) | 46/10 | 4.40 (1.56 to 12.45) | 0.06 |
*Frequencies represent children with no asthma/children with asthma phenotype under study. Children with missing data on GSTP1 Ile105Val were excluded.
†ORs represent odds ratios for asthma outcomes associated with high EPHX1 phenotype within each stratum of GSTP1 Ile105Val genotype and were adjusted for age, sex, race/ethnicity, in utero exposure to maternal smoking, number of smokers at home, community of residence, parental education, health insurance and parental history of asthma.
‡p values for the EPHX1 activity phenotype by GSTP1 Ile105Val genotype interactions were obtained from likelihood ratio tests from a non-stratified model with appropriate interaction terms and were based on 2df.