Normal controls | Eosinophilic asthma | Non-eosinophilic asthma | p Value(ANOVA) | p Value (eosinophilic vs non-eosinophilic) | |
Number (men) | 10 (5) | 12 (8) | 11 (3) | – | – |
Age (years) | 41 (22–61) | 42 (27–69) | 47 (19–68) | 0.65 | – |
FEV1 (% predicted) | 105 (3.9) | 90.3 (6.2) | 88 (4.9) | 0.05 | 0.96 |
FEV1/FVC | 82 (1.8) | 73.9 (2.9) | 69 (5.6) | 0.025 | 0.58 |
β2 agonist reversibilty (%) | 1.1 (0.9) | 9.5 (2.5) | 12.7 (3.4) | 0.001 | 0.67 |
Methacholine PC20 (mg/ml) | >16 | 0.67 (0.2) | 0.83 (0.2) | <0.001 | 0.15 |
Atopic (%) | 2 (20) | 8 (66) | 2 (18) | – | – |
Data given as mean (SE) except age which is given as mean (range) and methacholine PC20 which is given as geometric mean (log SE).
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; β2 agonist reversibility, percentage increase in FEV1 following inhalation of 200 μg salbutamol; methacholine PC20, concentration of inhaled methacholine which causes a 20% fall in FEV1.