Clinical manifestations suggestive of CF
| Highly suggestive | Suggestive but less specific |
|---|---|
| Gastrointestinal manifestations | Gastrointestinal manifestations |
| Meconium ileus Exocrine pancreatic insufficiency in children | Failure to thrive Hypoproteinaemia Deficiency of liposoluble vitamins Distal intestinal obstruction syndrome Rectal prolapse Biliary cirrhosis Portal hypertension Cholelithiasis in children without haemolytic disorder Primary sclerosing cholangitis Exocrine pancreatic insufficiency in adults Recurrent pancreatitis |
| Sinopulmonary manifestations | Sinopulmonary manifestations |
| Persistent respiratory infection with mucoid Pseudomonas aeruginosa Bronchiectasis in both upper lobes Persistent respiratory infection with Burkholderia cepacia Nasal polyps in children | Persistent or recurrent respiratory infections with Staphylococcus aureus, Pseudomonas aeruginosa, Achromobacter xylosoxidans or Haemophilus influenzae Radiological evidence of bronchiectasis, atelectasis, hyperinflation, or persistent infiltrates on chest radiograph Haemoptysis associated with diffuse pulmonary disease other than tuberculosis or vasculitis Chronic and/or productive cough Allergic bronchopulmonary aspergillosis Nasal polyps in adults Radiological evidence of chronic pansinusitis |
| Other | Other |
| Hypochloraemic alkalosis in the absence of vomiting Congenital bilateral absence of the vas deferens | Digital clubbing Osteopenia/osteoporosis <40 years of age Atypical diabetes |