Age | 47 (37–57) | 54 (47–61) | 51 (47–57) | 51 (47–52) |
Index cases | 7 | 15 | 17 | 15 |
Current smokers | 2 | 2 | 1 | 3 |
Pack years | 0 (0–5) | 20 (1–29) | 20 (15–36) | 20 (2–28) |
Sex (male) | 12 | 16 | 10 | 13 |
FEV1 (l)* | 3.8 (2.8–4.4) | 2.1 (1.8–2.3) | 1.1 (1.0–1.3) | 0.8 (0.6–1.0) |
FEV1 (% predicted) | 111.3 (94.1–123.0) | 61.8 (56.4–65.1) | 39.1 (35.7–42.5) | 25.9 (23.2–26.9) |
Kco* | 1.4 (1.2–1.6) | 1.1 (0.9–1.5) | 1.0 (0.8–1.1) | 0.7 (0.5–1.0) |
Kco (% predicted) | 93.3 (79.2–104.8) | 71.7 (60.2–94.8) | 63.5 (47.5–72.2) | 45.6 (35.6–62.3) |
UZ Perc15 | −917.9 (−935.9 to −906.2) | −942.4 (−960.1 to −920.5) | −944.3 (−969.7 to −934.4) | −961.7 (−979.6 to −947.7) |
LZ Perc15 | −920.1 (−938.6 to −903.0) | −968.1 (−978.7 to −944.1) | −975.7 (−979.1 to −965.5) | −976.7 (−985.6 to −967.4) |
Combined Perc15 | −919.3 (−937.2 to −900.2) | −955.1 (−969.2 to −932.4) | −958.8 (−972.2 to −952.3) | −969.9 (−983.7 to −957.6) |
UZ VI −950 | 3.8 (2.6–8.8) | 11.5 (4.7–20.5) | 12.5 (9.0–27.8) | 21.3 (14.0–34.6) |
LZ VI −950 | 5.7 (3.4–9.9) | 26.0 (11.6–38.2) | 32.6 (24.6–39.2) | 33.3 (26.6–44.2) |
Combined VI −950 | 5.2 (3.0–9.4) | 20.3 (9.5–29.2) | 24.5 (17.9–30.8) | 27.7 (20.3–44.5) |