Yamaguchi University, Japan(1993–4)24 | Clinical stage IA NSCLC,no mediastinoscopy | Video-assisted thoracoscopic lobectomy | Thoracotomy and conventional lobectomy | 100 | Overall 5 year survival |
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Lung Cancer Study Group Trial,North America (1982–8)22 | T1N0M0 peripheral NSCLC fit for lobectomy | Limited resection (wedge resection or segmentectomy, i.e. less than lobectomy) | Conventional lobectomy | 276 | Overall 5 year survival, local recurrence rate, death with cancer rate, pulmonary function |
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University of Munich and Central Hospital, Gauting, Germany(1989–91)13 | Resectable NSCLC(stages I–IIIA) | Thoracotomy, surgical resection, complete mediastinal lymph node dissection | Thoracotomy, surgical resection, systematic sampling of mediastinal lymph nodes | 201 | Overall and progression free survival (median follow up 47 months) |
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Yamaguchi University, Japan(1985–92)14 | Peripheral NSCLC<2 cm diameter,mediastinal and hilar lymph nodes <1 cm on CT (no mediastinoscopy) | Thoracotomy, surgical resection, complete mediastinal lymph node dissection | Thoracotomy, surgical resection, systematic sampling of mediastinal lymph nodes | 115 | Overall 5 year survival |
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Sun Yat-Sen University of Medical Sciences, Guangzhou, China(1989–95)15 | Pathologically confirmed NSCLC, clinical stages I–IIIA, age <71 years | Thoracotomy, surgical resection, complete mediastinal lymph node dissection | Thoracotomy, surgical resection, systematic sampling of mediastinal lymph nodes | 532 | Overall 5 year survival |