Change from baseline in diary card measurements
| Placebo(n = 318) | Salmeterol(n = 316) | p value*(median treatment difference) | 95% CI*(median treatment difference) | |
|---|---|---|---|---|
| *p values and confidence intervals were based on the distribution of the data (see Methods). | ||||
| Figures expressed as mean (SD). | ||||
| Use of salbutamol (times/day) | ||||
| Baseline | 2.58 (2.17) | 2.32 (1.99) | ||
| Mean change from baseline | −0.05 (1.30) | −0.49 (1.33) | <0.0001 | (−0.50 to 0.00) |
| Proportion of reliever-free days | ||||
| Baseline | 0.17 (0.33) | 0.21 (0.36) | ||
| Mean change from baseline | 0.04 (0.28) | 0.09 (0.30) | 0.009 | (0.00 to 0.0028) |
| % of days with mild or no cough | ||||
| Baseline | 45.6 (41.2) | 47.3 (42.8) | ||
| Mean change from baseline | 8.9 (33.40) | 7.3 (33.74) | 0.95 | (−2.62 to 2.89) |
| % of days breathless only on moderate exertion | ||||
| Baseline | 48.6 (42.4) | 48.9 (43.1) | ||
| Mean change from baseline | 1.60 (37.28) | 6.71 (33.67) | 0.027 | (0.00 to 6.96) |
| % of days with mild or no sputum | ||||
| Baseline | 50.8 (43.6) | 50.0 (43.9) | ||
| Mean change from baseline | 4.89 (31.94) | 5.46 (31.43) | 0.62 | (−1.05 to 2.93) |
| Mean number of nights with no awakenings | ||||
| Baseline | 0.55 (0.80) | 0.54 (0.86) | ||
| Mean change from baseline | −0.03 (0.60) | −0.08 (0.55) | 0.008 | (−0.07 to 0.00) |