Health outcome | Model 1† | Model 2 (Model 1+SABA)‡ | ||||
---|---|---|---|---|---|---|
ICS | SABA | ICS | ||||
β1 | p value | β2 | p value | β1 | p value | |
*All models included an adjustment for extra-Poisson due to year to year variability. | ||||||
†Model 1: Mortality: log (expected number of age-specific deaths due to asthma) = β0 × log (age specific population size) + β1 × steroids. Hospital admissions: log (expected number of age specific hospital admissions due to asthma) = β0 × log (age specific population size) + β1 × ICS. Thus, exp(β1×10 000) is the rate ratio of asthma mortality/hospital admissions per 10 000 units of medication sold. | ||||||
‡exp(β1×10 000) of ICS in model 2 is the adjusted rate ratio of asthma mortality/hospital admissions per 100 000 units of medication sold when SABA sales are held constant. | ||||||
Asthma mortality | ||||||
5–34 years | −0.0029 | 0.0179 | −0.0002 | 0.2782 | −0.0030 | 0.0394 |
35–64 years | −0.0023 | 0.0098 | 0.0023 | 0.2351 | −0.0046 | 0.0431 |
5–64 years | −0.0023 | 0.0196 | 0.0002 | 0.1826 | −0.0037 | 0.0461 |
Hospital admissions for asthma | ||||||
0–14 years | −0.0039 | 0.0003 | 0.0003 | 0.1676 | −0.0041 | 0.0004 |
15+ years | −0.0014 | 0.0030 | −0.0003 | 0.1515 | −0.0013 | 0.0165 |
All ages | −0.0024 | 0.0002 | −0.0771 | 0.0529 | −0.0024 | 0.0006 |