Characteristics of the study population
| COPD(n = 68) | No COPD(n = 81) | p value | |
|---|---|---|---|
| Figures are mean (SD), number (%), or median (interquartile range) as indicated. COPD is defined as a post-bronchodilator FEV1 of <80% predicted and FEV1/VC <0.7. | |||
| Mean (SD) age (years) | 57.9 (7.1) | 54.1 (8.7) | <0.01 |
| Male, n (%) | 53 (77.9) | 49 (60.5) | 0.02 |
| Probands, n (%) | 50 (73.5) | 0 | – |
| Siblings | 18 (26.5%) | 81 (100%) | – |
| Mean (SD) pack years smoked | 44.2 (28.8) | 25.5 (22.0) | <0.001 |
| Current smokers, n (%) | 32 (47.1) | 41 (50.6) | NS |
| Wrinkle score, median (IQR) | 2.25 (2) | 2 (1) | ⩽0.01 |
| Mean (SD) FEV1 (% predicted) | 41.9 (15.2) | 102.2 (16.0) | <0.001 |