TRISTAN31 | 719 | 1 | 44% | Salmererol 50 μg/fluticasone 500 μg twice daily | 25% reduction in rate of exacerbations. 39% reduction in rate of exacerbations requiring steroids |
Hanania90 | 363 | 0.5 | 42% | Salmererol 50 μg/fluticasone 500 μg twice daily | No difference in number of exacerbations and time to first exacerbation |
Calverley27 | 510 | 1 | 36% | Formoterol 24 μg/budesonide 400 μg twice daily | Prolonged time to first moderate exacerbation; risk reduction 42%. Reduced exacerbation rate by 24% |
Szafranski26 | 413 | 1 | 36% | Formoterol 24 μg/budesonide 400 μg twice daily | Reduced exacerbation rate from 1.87 to 1.42 per patient year |