Association between the quantitative trait of capsaicin sensitivity (C5) and NK-2R gene haplotypes in patients with chronic cough
| Haplotypes | N | C5† (μM/l) | p value* | |
|---|---|---|---|---|
| Mean | SD | |||
| *Non-parametric analysis methods. | ||||
| †The lowest capsaicin concentration that elicited five consecutive coughs. | ||||
| ‡In a recessive model of a haplotype (ht/ht v other haplotypes). | ||||
| 231Gly_375Arg/231Gly_375Arg | 39 | 64.1 | 56.6 | |
| 231Gly_375Arg/231Gly_375His | 26 | 60.9 | 56.3 | |
| 231Gly_375Arg/231Glu_375Arg | 107 | 55.8 | 54.8 | 0.03‡ |
| 231Gly_375His/231Glu_375Arg | 11 | 99.1 | 52.0 | |
| 231Glu_375Arg/231Glu_375Arg | 50 | 43.2 | 52.7 | |