Haplotype frequencies of non-synonymous SNPs of the NK-2R gene in relation to the capsaicin sensitivities of patients with chronic cough
| Haplotype | Capsaicin sensitivity† | p value* | OR (95% CI)‡ | |
|---|---|---|---|---|
| Positive (%) | Negative (%) | |||
| *χ2 test in a dominant model of a haplotype (ht/ht+ht/others v other haplotypes). | ||||
| †C5 ⩽16 μM/l. | ||||
| ‡Multiple logistic regression analysis after adjusting for confounding factors such as age, sex, smoking, and atopy. | ||||
| §p value corrected by Bonferroni’s method (uncorrected p = 0.003). | ||||
| 231Gly_375Arg | 43.9 | 51.3 | 0.06 | 0.72 (0.51 to 1.02) |
| 231Gly_375His | 9.0 | 13.0 | 0.12 | 0.66 (0.38 to 1.12) |
| 231Glu_375Arg | 46.8 | 35.8 | 0.01§ | 1.71 (1.20 to 2.24) |
| 231Glu_375His | 0.3 | 0.3 | 0.92 | 0.87 (0.05 to 14.09) |