Adjusted regression coefficients (with 95% confidence intervals) for association between inflammatory markers (log converted) and quadriceps strength, grip strength, and maximum inspiratory pressure (Pimax) in participants with and without obstructive lung disease (OLD)
| Variable | β with 95% confidence intervals* | |
|---|---|---|
| With OLD | Without OLD | |
| *β adjusted for age, race, sex, site, lean body mass, total fat, FEV1 % predicted, smoking status (current smokers, ever smoked versus never smoked), pack years of smoking, body mass index (>30 and <20 kg/m2), history of diabetes and congestive heart failure, and use of oral steroids interaction. p values for interaction between OLD and the association between individual inflammatory markers and muscle strength >0.5. | ||
| Quadriceps strength | ||
| IL-6 | −6.4 (−12.8 to −0.03) | −3.4 (−5.4 to −1.3) |
| TNF | −10.1 (−18.7 to −1.5) | −3.8 (−7 to −0.6) |
| CRP | −1.2 (−5.4 to 3.1) | −0.9 (−2.4 to 0.7) |
| Grip strength | ||
| IL-6 | −1.2 (−2.8 to 0.3) | −0.8 (−1.3 to −0.3) |
| TNF | −0.2 (−2.2 to 1.8) | −0.6 (−1.4 to 0.1) |
| CRP | 0.1 (−0.9 to 1.1) | −0.4 (−0.8 to −0.02) |
| Pimax | ||
| IL-6 | −4.2 (−10.3 to 1.8) | −0.8 (−3.1 to 1.5) |
| TNF | −6 (−14.7 to 2.7) | −3.5 (−7.1 to −0.003) |
| CRP | −1.2 (−5.3 to 2.9) | −0.02 (−1.7 to 1.8) |