Association between a quantitative trait of capsaicin sensitivity (C5) and individual SNPs of the NK-2R gene in patients with chronic cough
| Genotype | N | C5† (μM/l) | p value* | |
|---|---|---|---|---|
| Mean | SD | |||
| *Non-parametric methods in a dominant model of an allele, unless otherwise indicated. | ||||
| †The lowest capsaicin concentration that elicited five consecutive coughs. | ||||
| ‡In a recessive model (Glu/Glu v Gly/Gly + Gly/Glu). | ||||
| Gly231Glu | ||||
| Gly/Gly | 70 | 62.4 | 56.2 | |
| Gly/Glu | 115 | 60.0 | 55.8 | 0.04‡ |
| Glu/Glu | 52 | 44.1 | 53.2 | |
| Arg375His | ||||
| Arg/Arg | 191 | 54.2 | 55.1 | |
| Arg/His | 39 | 72.0 | 57.3 | 0.17 |
| His/His | 6 | 68.6 | 65.1 | |