Table 1

 Baseline characteristics of participants with and without obstructive lung disease (OLD)

VariableWith OLD(n = 268)Without OLD(n = 2005)p value
CHF, congestive heart failure; FEV1, forced expiratory volume in 1 second; CRP, C-reactive protein; IL, interleukin; TNF, tumour necrosis factor.
Data expressed as mean (SD) unless specified otherwise.
†Data log converted since distribution not normal.
‡Median with interquartile range.
Demographic characteristics
    Age73.6 (2.8)73.2 (2.8)0.03
    Sex (% male)58500.02
    Race (% black)56620.03
    Site (% Memphis)51490.4
Co-morbid conditions
    Hypertension (%)47500.3
    Diabetes (%)14150.4
    History of CHF (%)0.81.20.8
    History of COPD (%)41.810.6<0.0001
    Current smoking (%)329<0.0001
    Past smoking (%)5446
    Pack years of smoking‡39 (9–57)2 (0–25)<0.0001
    Depression (%)11.412.50.6
Pulmonary function
    FEV1 (% predicted)65.1 (16.6)98.6 (18.2)<0.0001
        Mild ⩾70% predicted (%)35100
        Moderate 51–70% predicted (%)380
        Severe <50% predicted (%)270
Body composition
    Body mass index (kg/m2)25.4 (4.7)27.4 (4.7)0.001
    Visceral adiposity (cm2)149.4 (77)146.9 (67)0.4
    Lean body mass (kg)47 (10)48 (10)0.008
    Weight (kg)72 (14)76 (15)<0.0001
Muscle strength and muscle mass
    Grip strength (kg)34.1 (8)32.5 (7)0.3
    Knee extensor strength (Nm)102.5 (39)108.9 (38)0.017
    Thigh muscle area by CT scan (cm2)102 (39)108 (39)0.002
    Lower limb lean mass by DXA (kg)7.4 (1.7)7.6 (1.8)0.04
    Knee extensor strength/thigh muscle area by CT scan (Nm/cm2)0.95 (0.24)0.95 (0.22)0.9
    Maximal inspiratory pressure (cm H2O)64.7 (30)74.2 (32)<0.0001
Inflammatory markers†
    TNF (pg/ml)3.4 (1.7)3.4 (1.5)0.3
    IL-6 (pg/ml)2.6 (1.9)2.2 (1.8)<0.0001
    CRP (mg/l)3.5 (5.3)2.5 (3.7)<0.0001
Medications
    Steroids (%)4.51.20.006