Frequencies of individual SNPs and haplotypes of the NK-2R gene in patients with chronic cough and age matched healthy controls
| Genotypes | Patients(N = 312) | Controls†(N = 100) | p value* | |
|---|---|---|---|---|
| *χ2 test (patients v controls). | ||||
| †Age matched healthy controls. | ||||
| Codon 231 | Gly/Gly | 107 (36.5%) | 30 (30%) | 0.87 |
| Gly/Glu | 131 (44.7%) | 50 (50%) | ||
| Glu/Glu | 55 (18.8%) | 20 (20%) | ||
| Codon 375 | Arg/Arg | 229 (78.7%) | 79 (79%) | 0.83 |
| Arg/His | 56 (19.2%) | 17 (17%) | ||
| His/His | 6 (2.1%) | 4 (4%) | ||
| Haplotypes | 231Gly_375Arg | 47.8% | 42.5% | 0.69 |
| 231Gly_375His | 11.1% | 12.5% | ||
| 231Glu_375Arg | 40.5% | 45.0% | ||
| 231Glu_375His | 0.4% | 0% | ||