Characteristics of patients: pretreatment (PreT) and baseline (BTr) total AAT concentrations (measured by nephelometry and expressed in g/l)
| Patient no | Wt | Age | Sex | PH | FEV1 | PreT | BTr | PD | OD7 | OD14 | OD21 | ΔOD21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wt, weight (kg); F, female; M, male; PH, phenotype; FEV1, forced expiratory volume in 1 second in litres (% predicted); PD, previous dose every 21 days in grams; OD, optimal dose in grams; ΔOD21, percentage of the relative total dose increase of Prolastina between previous doses and OD21. | ||||||||||||
| 1 | 64 | 52 | F | YY | 0.92 (39) | 0.09 | 0.09 | 12 | 4 | 14 | 33 | 175 |
| 2 | 51 | 52 | F | ZZ | 1.13 (44) | 0.23 | 0.31 | 10 | 2 | 7 | 20 | 100 |
| 3 | 75 | 50 | M | ZZ | 1.01 (26) | 0.24 | 0.36 | 13 | 2 | 9 | 22 | 69 |
| 4 | 58 | 56 | F | ZZ | 1.02 (40) | 0.23 | 0.34 | 11 | 2 | 7 | 20 | 82 |
| 5 | 68 | 68 | F | ZZ | 0.82 (38) | 0.24 | 0.32 | 12 | 2 | 8 | 21 | 75 |
| 6 | 58 | 50 | F | ZZ | 1.22 (48) | 0.26 | 0.38 | 11 | 2 | 6 | 16 | 45 |