Table 3

Results of transmission disequilibrium test (TDT)

SFRS8*		Sample 1					Sample 2					Sample 1 and 2
	Model	Allele	Fam‡	S§	E(S)¶	p	Allele	Fam	S	E(S)	p	Allele	Fam	S	E(S)	p
*Ref Seq NM_004592.
†Only association to one allele is shown for the additive model due to one degree of freedom in this model.
‡Number of informative families (families with minimum of one heterozygous parent).
§FBAT score statistics.
¶Expected FBAT score statistics, given no association.³² For the additive model S can be regarded as observed number of alleles transmitted and E(S) as the expected number of alleles transmitted, given no association.
**Association not tested if number of informative families <10.
††p values in parentheses are calculated using the empirical variance, which means H₀ = linkage but no association.³⁴ p values ⩽0.05 are shown in bold.
rs1379049	Additive†	g	19	20	18	0.50	g	52	50	56	0.26	g	71	70	74	0.51
	Recessive	g	1			**	g	9			**	g	10	4	4.75	0.69
	Recessive	a	19	14	16.5	0.39	a	52	49	43.25	0.23	a	71	63	59.75	0.56
rs3782288	Additive	g	19	48	50	0.50	g	52	143	136	0.19	g	71	191	186	0.42
	Recessive	g	19	14	16.5	0.39	g	52	50	43.75	0.19	g	71	64	60.25	0.50
	Recessive	a	1			**	a	10	4	4.75	0.69	a	11	4	5.25	0.53
rs930863	Additive	c	28	65	64.5	0.90	c	105	211	214.5	0.66	c	133	276	279	0.74
	Recessive	c	23	19	19	1.00	c	80	63	58.75	0.46	c	103	82	77.75	0.52
	Recessive	a	11	7	7.5	0.81	a	57	46	38.25	0.11	a	68	53	45.75	0.17
rs1051219	Additive	t	26	63	64	0.78	t	85	184	190.5	0.35	t	111	247	254	0.34
	Recessive	t	23	20	20.25	0.94	t	79	58	58	1.00	t	102	78	78.25	0.97
	Recessive	c	6			**	c	29	23	16.5	0.050 (0.12)††	c	35	27	19.75	0.043 (0.10)
rs1107871	Additive	g	28	56	61	0.25	g	110	222	224	0.80	g	138	278	285	0.45
	Recessive	g	24	16	17.5	0.64	g	86	62	62	1.00	g	111	78	79.5	0.82
	Recessive	a	15	12	8.5	0.14	a	58	40	38	0.68	a	73	52	46.5	0.30
rs1051233	Additive	c	26	62	64.5	0.48	c	83	187	192.5	0.41	c	109	249	257	0.29
	Recessive	c	23	19	20.5	0.64	c	78	61	60.25	0.89	c	101	80	80.75	0.91
	Recessive	g	5			**	g	22	18	11.75	0.025 (0.079)	g	27	22	14.75	0.018 (0.057)
rs755437	Additive	c	29	54	56	0.63	c	112	239	217	0.0068 (0.017)	c	141	293	273	0.028 (0.050)
	Recessive	c	21	12	14.75	0.34	c	82	76	58.25	0.0020 (0.0079)	c	103	88	73	0.020 (0.043)
	Recessive	t	16	11	11.75	0.77	t	65	38	42.25	0.40	t	81	49	54	0.38