Table 1

Expected exogenous minimum AAT concentrations at steady state (SS) conditions (C_min^SS) obtained from 1000 simulations expressed as mean, 5th and 95th percentiles. Expected total AAT concentrations (exogenous plus native) are shown in brackets

Dosage regimen	Mean exogenous AAT C_min^SS	5th percentile	95th percentile
60 mg/kg/7 days	0.73 (0.97)	0.31 (0.55)	1.03 (1.27)
50 mg/kg/7 days	0.61 (0.85)	0.28 (0.52)	1.18 (1.42)
120 mg/kg/14 days	0.34 (0.58)	0.15 (0.40)	0.68 (0.92)
100 mg/kg/14 days	0.28 (0.52)	0.12 (0.36)	0.51 (0.75)
180 mg/kg/21 days	0.23 (0.47)	0.09 (0.33)	0.46 (0.70)
150 mg/kg/21 days	0.19 (0.43)	0.08 (0.32)	0.41 (0.65)
250 mg/kg/28 days	0.19 (0.43)	0.05 (0.29)	0.31 (0.55)