Pre-randomisation allergen challenge(n = 54) | End of treatment allergen challenge | p value FP v FP/S | ||
---|---|---|---|---|
Fluticasone (FP)(n = 23) | Fluticasone/salmeterol (FP/S)(n = 27) | |||
Data shown as geometric mean (95% confidence interval) values. | ||||
The increases were calculated from the levels 24 hours after relative to the levels 24 hours before the bronchial allergen challenges. | ||||
ECP, eosinophil cationic protein; RCEs, relative coefficient of excretion, representing the ratio of α2-macroglobulin to albumin in induced sputum. | ||||
Sputum eosinophils (n) | 3.7 (1.9 to 7.1) | 4.4 (2.4 to 8.1) | 2.6 (1.0 to 6.8) | 0.33 |
Sputum eosinophils (%) | 2.4 (1.5 to 3.8) | 3.4 (1.9 to 6.1) | 1.8 (0.9 to 3.8) | 0.09 |
Sputum ECP | 2.0 (1.2 to 3.4) | 2.1 (1.0 to 4.4) | 1.4 (0.7 to 2.5) | 0.18 |
RCEs | 1.4 (1.0 to 1.8) | 0.8 (0.5 to 1.3) | 1.3 (0.9 to 1.8) | 0.15 |
Sputum α2-macroglobulin | 1.3 (1.0 to 1.7) | 1.2 (0.7 to 2.0) | 1.0 (0.7 to 1.5) | 0.34 |
Sputum albumin | 0.9 (0.6 to 1.3) | 1.5 (0.9 to 2.5) | 0.8 (0.5 to 1.3) | 0.27 |