Demographic, clinical, and haemodynamic characteristics of patients at the time of PH diagnosis
| Group A(n = 7) | Group B(n = 15) | |
|---|---|---|
| Group A, patients without pulmonary fibrosis on the chest radiograph; group B, patients with pulmonary fibrosis on the chest radiograph; mRAP, mean right atrial pressure; mPAP, mean pulmonary artery pressure; PWP, pulmonary wedge pressure; CI, cardiac index; PVRI, pulmonary vascular resistance index; SvO2, mixed venous oxygen saturation. | ||
| *Time interval between the first symptoms related to sarcoidosis and the diagnosis of PH. | ||
| †Acute vasodilator response was tested with a short term intravenous infusion of epoprostenol or inhaled nitric oxide. A positive response was defined by a fall both in mPAP and PVRI of ⩾20%. | ||
| ‡Nine patients in group B were not tested. | ||
| Age (years) | 48 (13) | 45 (13) |
| M/F | 3/4 | 13/2 |
| White/black | 4/3 | 13/2 |
| Non/ex/current smokers | 4/3/0 | 6/7/2 |
| Mean (SD) time interval between sarcoidosis and PH (years)* | 3.7 (3.1) | 12.5 (6.2) |
| NYHA functional class, n (%) | ||
| I | 1 (14.3) | |
| II | 4 (57.1) | 2 (13.3) |
| III | 2 (28.6) | 8 (53.3) |
| IV | 5 (33.3) | |
| Right heart failure, n (%) | 1 (14.3) | 4 (26.7) |
| Near syncope, n (%) | 0 | 3 (20) |
| Mean (SD) baseline haemodynamics | ||
| mRAP (mm Hg) | 7.3 (4.2) | 6.4 (6.7) |
| mPAP (mm Hg) | 51.7 (16.0) | 40.1 (11.6) |
| PWP (mm Hg) | 8.8 (2.3) | 8.1 (3.6) |
| CI (l/min/m2) | 2.45 (0.69) | 3.26 (0.09) |
| PVRI (IU/m2) | 23.0 (10.4) | 14.6 (8.9) |
| Svo2 (%) | 63 (16) | 68 (9) |
| Acute vasodilator response, n (%)†‡ | 0 (0) | 0 (0) |