Naïve | Asthma | Asthma + HyPE | Asthma + Dx | |
---|---|---|---|---|
I, Infiltration of inflammatory cells into the space between the intima and adventitia of the bronchi, expressed as number of inflammatory cells per mm of basal membrane. II, Airway smooth muscle (ASM) thickening expressed as width of ASM per length of basal membrane (μm/mm). III, Thickening of basal membrane expressed as width (μm) per length (mm) of basement membrane. IV, Mucus metaplasia of respiratory epithelial cells expressed as the percentage of PAS positive cells from total epithelial cells. | ||||
Data are mean (SE) values for 10 rats. For all parameters, statistical analysis showed a significant difference (p<0.001) between non-treated asthmatic rats and the other groups, and no significant difference between HyPE treated and naïve or dexamethasone (Dx) treated rats. | ||||
(I) Inflammatory cell infiltration | 1.16 (0.11) | 11.41 (1.81) | 1.44 (0.21) | 1.41 (0.16) |
(II) Airway smooth muscle thickening | 3.96 (0.39) | 40.20 (4.78) | 5.03 (0.65) | 7.10 (0.96) |
(III) Basement membrane thickening | 0.76 (0.20) | 8.22 (1.20) | 0.70 (0.09) | 0.69 (0.08) |
(IV) Mucus metaplasia | 12.0 (1.3) | 67.0 (3.2) | 13.0 (4.1) | 11.0 (3.5) |