Adjusted risk of clinical outcomes in the Lung Health Study cohort according to quintiles of baseline CRP levels
| Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | p for trend† | |
|---|---|---|---|---|---|---|
| CRP, C-reactive protein; CHD, coronary heart disease; CVD, cardiovascular disease. | ||||||
| *Geometric mean value for each quintile of CRP. | ||||||
| †Linear trend from quintile 1 to quintile 5. | ||||||
| All values are mean (95% CI) and have been adjusted for sex, race, age (in quintiles), body mass index (in quintiles), pack-years of smoking (in quintiles), biochemically validated smoking status (continued smokers, sustained quitters, or intermittent quitters), rate of decline in FEV1 (in quintiles), and predicted FEV1 (in quintiles). | ||||||
| Mean CRP (mg/l)* | 0.21 | 0.73 | 1.39 | 2.58 | 7.06 | |
| All-cause mortality | 1.0 | 0.98 (0.65 to 1.46) | 1.14 (0.78 to 1.68) | 1.13 (0.77 to 1.65) | 1.79 (1.25 to 2.56) | <0.001 |
| CHD deaths | 1.0 | 0.56 (0.18 to 1.79) | 0.93 (0.34 to 2.60) | 0.87 (0.32 to 2.39) | 2.20 (0.90 to 5.38) | 0.016 |
| CVD deaths | 1.0 | 0.43 (0.17 to 1.09) | 1.08 (0.52 to 2.34) | 0.90 (0.43 to 1.89) | 1.69 (0.86 to 3.33) | 0.014 |
| Fatal/non-fatal CHD | 1.0 | 0.98 (0.71 to 1.35) | 1.02 (0.74 to 1.40) | 1.26 (0.93 to 1.71) | 1.56 (1.15 to 2.10) | <0.001 |
| Fatal/non-fatal CVD | 1.0 | 0.91 (0.71 to 1.17) | 1.02 (0.80 to 1.31) | 1.18 (0.93 to 1.49) | 1.51 (1.20 to 1.90) | <0.001 |
| Cancer deaths | 1.0 | 1.39 (0.80 to 2.43) | 1.20 (0.68 to 2.11) | 1.43 (0.83 to 2.47) | 1.85 (1.10 to 3.13) | 0.027 |
| Lung cancer deaths | 1.0 | 1.66 (0.83 to 3.28) | 1.00 (0.47 to 2.11) | 1.31 (0.64 to 2.66) | 1.76 (0.89 to 3.45) | 0.243 |
| Respiratory deaths | 1.0 | 0.36 (0.09 to 1.36) | 0.65 (0.22 to 1.90) | 0.31 (0.08 to 1.20) | 0.59 (0.20 to 1.78) | 0.310 |