Table 3

Allele and genotype distribution in asthma patients and non-asthmatic controls

Polymorphism†				Total		Asthma disease severity
Polymorphism†				Non-asthma	All asthma	Mild	Moderate	Severe
†MMP-9 −861C>T and TIMP-1 323C>T (Pro87Pro) were not informative in this population (with allele frequencies of <1%), MMP-9 −1702T>A and TIMP-1 595C>T (Ser178Phe) were not detectable in this population.
‡As the TIMP-1 gene is on the X chromosome, the results have been analysed by sex.
MMP-9
−1562C>T		N		392	514	242	201	71
		Genotype	cc	0.74	0.71	0.76	0.74	0.66
			ct	0.24	0.26	0.22	0.25	0.30
			tt	0.02	0.03	0.02	0.01	0.04
		Allele	C	0.86	0.84	0.87	0.87	0.80
			T	0.14	0.16	0.13	0.13	0.20

836G>A (Arg279Gln)		N		406	543	259	213	71
		Genotype	AA	0.46	0.43	0.44	0.43	0.39
			AG	0.43	0.43	0.43	0.44	0.49
			GG	0.11	0.14	0.13	0.13	0.12
		Allele	A	0.68	0.64	0.65	0.65	0.65
			G	0.32	0.36	0.35	0.35	0.35

TIMP-1‡
434T>C (Phe124Phe)	Women	N		34	142	46	51	45
		Genotype	CC	0.27	0.27	0.28	0.20	0.33
			CT	0.44	0.58	0.63	0.65	0.49
			TT	0.29	0.15	0.09	0.15	0.18
		Allele	C	0.48	0.56	0.60	0.52	0.58
			T	0.52	0.44	0.40	0.48	0.42
	Men	N		33	78	31	21	26
		Allele	C	0.49	0.68	0.52	0.71	0.69
			T	0.51	0.32	0.48	0.29	0.31

536C>T (Ile158Ile)	Women	N		221	350	166	138	46
		Genotype	CC	0.99	0.94	0.94	0.96	0.93
			CT	0.01	0.05	0.05	0.04	0.07
			TT	0.00	0.01	0.01	0.00	0.00
		Allele	C	0.99	0.97	0.96	0.98	0.96
			T	0.01	0.03	0.04	0.02	0.04
	Men	N		183	200	97	77	26
		Allele	C	0.98	0.97	1.00	0.97	0.92
			T	0.02	0.03	0.00	0.03	0.08