Polymorphism† | Total | Asthma disease severity | ||||||
---|---|---|---|---|---|---|---|---|
Non-asthma | All asthma | Mild | Moderate | Severe | ||||
†MMP-9 −861C>T and TIMP-1 323C>T (Pro87Pro) were not informative in this population (with allele frequencies of <1%), MMP-9 −1702T>A and TIMP-1 595C>T (Ser178Phe) were not detectable in this population. | ||||||||
‡As the TIMP-1 gene is on the X chromosome, the results have been analysed by sex. | ||||||||
MMP-9 | ||||||||
−1562C>T | N | 392 | 514 | 242 | 201 | 71 | ||
Genotype | cc | 0.74 | 0.71 | 0.76 | 0.74 | 0.66 | ||
ct | 0.24 | 0.26 | 0.22 | 0.25 | 0.30 | |||
tt | 0.02 | 0.03 | 0.02 | 0.01 | 0.04 | |||
Allele | C | 0.86 | 0.84 | 0.87 | 0.87 | 0.80 | ||
T | 0.14 | 0.16 | 0.13 | 0.13 | 0.20 | |||
836G>A (Arg279Gln) | N | 406 | 543 | 259 | 213 | 71 | ||
Genotype | AA | 0.46 | 0.43 | 0.44 | 0.43 | 0.39 | ||
AG | 0.43 | 0.43 | 0.43 | 0.44 | 0.49 | |||
GG | 0.11 | 0.14 | 0.13 | 0.13 | 0.12 | |||
Allele | A | 0.68 | 0.64 | 0.65 | 0.65 | 0.65 | ||
G | 0.32 | 0.36 | 0.35 | 0.35 | 0.35 | |||
TIMP-1‡ | ||||||||
434T>C (Phe124Phe) | Women | N | 34 | 142 | 46 | 51 | 45 | |
Genotype | CC | 0.27 | 0.27 | 0.28 | 0.20 | 0.33 | ||
CT | 0.44 | 0.58 | 0.63 | 0.65 | 0.49 | |||
TT | 0.29 | 0.15 | 0.09 | 0.15 | 0.18 | |||
Allele | C | 0.48 | 0.56 | 0.60 | 0.52 | 0.58 | ||
T | 0.52 | 0.44 | 0.40 | 0.48 | 0.42 | |||
Men | N | 33 | 78 | 31 | 21 | 26 | ||
Allele | C | 0.49 | 0.68 | 0.52 | 0.71 | 0.69 | ||
T | 0.51 | 0.32 | 0.48 | 0.29 | 0.31 | |||
536C>T (Ile158Ile) | Women | N | 221 | 350 | 166 | 138 | 46 | |
Genotype | CC | 0.99 | 0.94 | 0.94 | 0.96 | 0.93 | ||
CT | 0.01 | 0.05 | 0.05 | 0.04 | 0.07 | |||
TT | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | |||
Allele | C | 0.99 | 0.97 | 0.96 | 0.98 | 0.96 | ||
T | 0.01 | 0.03 | 0.04 | 0.02 | 0.04 | |||
Men | N | 183 | 200 | 97 | 77 | 26 | ||
Allele | C | 0.98 | 0.97 | 1.00 | 0.97 | 0.92 | ||
T | 0.02 | 0.03 | 0.00 | 0.03 | 0.08 |